| Autor: |
Kermani F; Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Mashhad 9177948564, Iran., Sadidi H; Thoracic Surgery Department, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad 917699311, Iran., Ahmadabadi A; Department of General Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.; Surgical Oncology Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad 9176999311, Iran., Hoseini SJ; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Tavousi SH; Department of General Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Rezapanah A; Department of General Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Nazarnezhad S; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Hosseini SA; Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Mollazadeh S; Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Mashhad 9177948564, Iran., Kargozar S; Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran. |
| Abstrakt: |
In this study, we successfully utilized nitrate precursors for the synthesis of silver (Ag)-doped borate-based mesoporous bioactive glass (MBGs) based on the 1393B3 glass formulation in the presence of a polymeric substrate (polyvinyl alcohol (PVA)) as a stabilizer of boric acid. The X-ray diffraction (XRD) analysis confirmed the glassy state of all the MBGs. The incorporation of 7.5 mol% Ag into the glass composition led to a decrease in the glass transition temperature (T g ). Improvements in the particle size, zeta potential, surface roughness, and surface area values were observed in the Ag-doped MBGs. The MBGs (1 mg/mL) had no adverse effect on the viability of fibroblasts. In addition, Ag-doped MBGs exhibited potent antibacterial activity against gram-positive and gram-negative species. In summary, a modified sol-gel method was confirmed for producing the Ag-doped 1393B3 glasses, and the primary in vitro outcomes hold promise for conducting in vivo studies for managing burns. |
