| Autor: |
Martínez-Ortega AJ; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío., Piñar Gutiérrez A; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío., Lara-Romero C; Servicio de Gastroenterología. Hospital Universitario Virgen del Rocío., Remón Ruiz PJ; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío., Ampuero-Herrojo J; Servicio de Gastroenterología. Hospital Universitario Virgen del Rocío., de Lara-Rodríguez I; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío., Romero-Gómez M; Servicio de Gastroenterología. Hospital Universitario Virgen del Rocío., García Luna PP; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío., Soto-Moreno A; Servicio de Endocrinología y Nutrición. Hospital Universitario Virgen del Rocío. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutricion hospitalaria [Nutr Hosp] 2022 Oct 17; Vol. 39 (5), pp. 1012-1018. |
| DOI: |
10.20960/nh.03969 |
| Abstrakt: |
Introduction: Background: type 2 diabetes (T2D) is a risk factor for nonalcoholic fatty liver disease (NAFLD). Objective: to evaluate the prevalence of NAFLD in a cohort of patients with T2D. Methods: an observational, descriptive study performed between May 2018 and December 2019 at the Endocrinology and Nutrition Unit. The χ² test was performed for qualitative variables and a non-parametric test for the comparison of medians of quantitative variables. Steatosis degree was defined by the coefficient attenuated parameter (CAP): (S0: < 248 dB/m; S1: 248-268 dB/m; S2: 268-288 dB/m; S3: > 288 dB/m) or stiffness: F0-F1: < 8 kPa; F2: 8-10 kPa; F3: 10-15 kPa; F4: > 15 kPa, using transient elastography (TE) (FibroScan®). A univariate analysis was performed and subsequently a multivariate analysis with statistically significant variables used to study the predictive factors of intense steatosis and advanced fibrosis. Results: n = 104 patients with T2D; 84 (80.7 %) were obese. TE demonstrated advanced fibrosis in 20 % and intense steatosis (S3) in more than 50 %. Lower total bilirubin (OR: 0.028; 95 % CI: (0.002-0.337); p = 0.005) was found to be an independent factor for S3 steatosis in the multivariate analysis. BMI ((OR: 1.497; 95 % CI: (1.102-2.034); p = 0.01)) was a predictive factor for advanced fibrosis in a multivariate analysis. Conclusions: NAFLD-associated intense steatosis and NAFLD-associated fibrosis were commonly found in patients with T2DM and obesity. Diabetic patients should be screened for liver disease as one more target organ. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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