Chemotherapy for Metastatic Gastric Cancer: Does Age Matter? A Single-Center, Retrospective, Real-World Study.

Autor: Liao PW; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung., Cheng SB; Division of General Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung.; School of Medicine, Chung Shan Medical University, Taichung., Chou CW; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung., Lin HC; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung., Lin CH; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung., Chen TC; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei., Hsu CY; Biostatistics Task Force, Taichung Veterans General Hospital, Taichung., Jerry Teng CL; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung.; School of Medicine, Chung Shan Medical University, Taichung.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung.; Department of Life Science, Tunghai University, Taichung., Shih YH; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung.; School of Medicine, Chung Shan Medical University, Taichung.; Institute of Medicine, Chung Shan Medical University, Taichung.
Jazyk: angličtina
Zdroj: Clinical Medicine Insights. Oncology [Clin Med Insights Oncol] 2022 Sep 18; Vol. 16, pp. 11795549221123617. Date of Electronic Publication: 2022 Sep 18 (Print Publication: 2022).
DOI: 10.1177/11795549221123617
Abstrakt: Background: Palliative chemotherapy is the preferred standard of care for patients with metastatic gastric cancer (mGC). It remains uncertain whether older patients with mGC would benefit from palliative chemotherapy. This study aimed to investigate the clinical impact of palliative chemotherapy in older patients with mGC.
Methods: This single-institute, retrospective, and real-world study included 428 patients with mGC between January 2009 and December 2019. Among them, 306 who received palliative chemotherapy were further stratified into 2 groups according to age: ≤70 (n = 236) and >70 (n = 70) years. The clinical demographics, outcomes, and hematologic toxicities of chemotherapy were compared between the 2 groups. Prognostic factors were determined using the Cox proportional hazards model.
Results: Of the screened 428 patients, older patients had worse overall survival (OS) than younger patients. Among patients who received chemotherapy (n = 306), patients aged >70 and ⩽70 years had comparable progression-free survival (PFS) and OS. The incidence of severe hematologic toxicity was similar between the 2 groups. The Eastern Cooperative Oncology Group performance status of 2 or more metastatic sites, elevated carbohydrate antigen 19-9 level, high neutrophil-to-lymphocyte ratio (NLR), and undergoing palliative gastrectomy were independent prognostic factors for OS. Notably, age >70 years was not a significant factor for poor OS.
Conclusions: Older age of >70 years might not be considered an obstacle to administering palliative chemotherapy to patients with mGC.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: C-LJT received an honorarium and consulting fees from Novartis, Roche, Takeda, Johnson & Johnson, Amgen, BMS Celgene, Kirin, and MSD. The other authors declare that they have no conflicts of interest.
(© The Author(s) 2022.)
Databáze: MEDLINE
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