Antimicrobial activity of graphene oxide quantum dots: impacts of chemical reduction.
| Autor: | Rojas-Andrade MD; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Nguyen TA; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Mistler WP; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Armas J; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Lu JE; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Roseman G; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Hollingsworth WR; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Nichols F; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Millhauser GL; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Ayzner A; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu., Saltikov C; Department of Microbiology and Environmental Toxicology, University of California 1156 High Street Santa Cruz California 95064 USA saltikov@ucsc.edu., Chen S; Department of Chemistry and Biochemistry, University of California 1156 High Street Santa Cruz California 95064 USA shaowei@ucsc.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Nanoscale advances [Nanoscale Adv] 2020 Jan 20; Vol. 2 (3), pp. 1074-1083. Date of Electronic Publication: 2020 Jan 20 (Print Publication: 2020). |
| DOI: | 10.1039/c9na00698b |
| Abstrakt: | Design and engineering of graphene-based functional nanomaterials for effective antimicrobial applications has been attracting extensive interest. In the present study, graphene oxide quantum dots (GOQDs) were prepared by chemical exfoliation of carbon fibers and exhibited apparent antimicrobial activity. Transmission electron microscopic measurements showed that the lateral length ranged from a few tens to a few hundred nanometers. Upon reduction by sodium borohydride, whereas the UV-vis absorption profile remained largely unchanged, steady-state photoluminescence measurements exhibited a marked blue-shift and increase in intensity of the emission, due to (partial) removal of phenanthroline-like structural defects within the carbon skeletons. Consistent results were obtained in Raman and time-resolved photoluminescence measurements. Interestingly, the samples exhibited apparent, but clearly different, antimicrobial activity against Staphylococcus epidermidis cells. In the dark and under photoirradiation (400 nm), the as-produced GOQDs exhibited markedly higher cytotoxicity than the chemically reduced counterparts, likely because of (i) effective removal by NaBH Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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