Amyloidosis of the Heart and Kidney.
| Autor: | Adrogue HE; Division of Nephrology, Transplantation, and Hypertension, Department of Medicine, Houston Methodist Hospital, Houston, Texas, US.; Texas A&M Medical School, Houston, Texas, US. |
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| Jazyk: | angličtina |
| Zdroj: | Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2022 Sep 06; Vol. 18 (4), pp. 27-33. Date of Electronic Publication: 2022 Sep 06 (Print Publication: 2022). |
| DOI: | 10.14797/mdcvj.1150 |
| Abstrakt: | Amyloidosis encompasses a collection of disorders of pathological protein folding. The extracellular location where these "amyloid fibril" proteins are deposited determines the clinical presentation of the disease. The abnormal architecture of these fibrils makes them insoluble and not easily removed, leading to disruption of normal tissue structure and interference with normal physiology. Amyloidosis of the heart and kidney can be inherited, secondary to unrelated diseases, or due to a plasma cell disorder. This review will focus on immunoglobulin light chain amyloidosis, which is life-threatening and must be diagnosed as early as possible by employing precise and accurate typing to ensure timely and frequently curative therapy. Competing Interests: The author has no competing interests to declare. (Copyright: © 2022 The Author(s).) |
| Databáze: | MEDLINE |
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