Multi-directional electrodeposited gold nanospikes for antibacterial surface applications.

Autor: Elbourne A; School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia russell.crawford@rmit.edu.au., Coyle VE; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia., Truong VK; School of Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology Haw-thorn VIC 3122 Australia.; ARC Research Hub for Australian Steel Manufacturing Wollongong New South Wales Australia., Sabri YM; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia., Kandjani AE; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia., Bhargava SK; Centre for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia., Ivanova EP; School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia russell.crawford@rmit.edu.au., Crawford RJ; School of Science, College of Science, Engineering and Health, RMIT University Melbourne VIC 3001 Australia russell.crawford@rmit.edu.au.
Jazyk: angličtina
Zdroj: Nanoscale advances [Nanoscale Adv] 2018 Aug 21; Vol. 1 (1), pp. 203-212. Date of Electronic Publication: 2018 Aug 21 (Print Publication: 2019).
DOI: 10.1039/c8na00124c
Abstrakt: The incorporation of high-aspect-ratio nanostructures across surfaces has been widely reported to impart antibacterial characteristics to a substratum. This occurs because the presence of such nanostructures can induce the mechanical rupture of attaching bacteria, causing cell death. As such, the development of high-efficacy antibacterial nano-architectures fabricated on a variety of biologically relevant materials is critical to the wider acceptance of this technology. In this study, we report the antibacterial behavior of a series of substrata containing multi-directional electrodeposited gold (Au) nanospikes, as both a function of deposition time and precursor concentration. Firstly, the bactericidal efficacy of substrata containing Au nanospikes was assessed as a function of deposition time to elucidate the nanopattern that exhibited the greatest degree of biocidal activity. Here, it was established that multi-directional nanospikes with an average height of ∼302 nm ± 57 nm (formed after a deposition time of 540 s) exhibited the greatest level of biocidal activity, with ∼88% ± 8% of the bacterial cells being inactivated. The deposition time was then kept constant, while the concentration of the HAuCl 4 and Pb(CH 3 COO) 2 precursor materials (used for the formation of the Au nanospikes) was varied, resulting in differing nanospike architectures. Altering the Pb(CH 3 COO) 2 precursor concentration produced multi-directional nanostructures with a wider distribution of heights, which increased the average antibacterial efficacy against both Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacteria. Importantly, the in situ electrochemical fabrication method used in this work is robust and straightforward, and is able to produce highly reproducible antibacterial surfaces. The results of this research will assist in the wider utilization of mechano-responsive nano-architectures for antimicrobial surface technologies.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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