Emulsion electrospinning of sodium alginate/poly(ε-caprolactone) core/shell nanofibers for biomedical applications.

Autor:	Norouzi MR; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles Lerchenfeldstrasse 5 CH-9014 St. Gallen Switzerland rene.rossi@empa.ch.; Department of Textile Engineering, Isfahan University of Technology Isfahan 84156-83111 Iran laleh.ghasemi@cc.iut.ac.ir., Ghasemi-Mobarakeh L; Department of Textile Engineering, Isfahan University of Technology Isfahan 84156-83111 Iran laleh.ghasemi@cc.iut.ac.ir., Itel F; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles Lerchenfeldstrasse 5 CH-9014 St. Gallen Switzerland rene.rossi@empa.ch., Schoeller J; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles Lerchenfeldstrasse 5 CH-9014 St. Gallen Switzerland rene.rossi@empa.ch.; ETH Zürich, Department of Health Science and Technology 8092 Zürich Switzerland., Fashandi H; Department of Textile Engineering, Isfahan University of Technology Isfahan 84156-83111 Iran laleh.ghasemi@cc.iut.ac.ir., Borzi A; Empa, Swiss Federal Laboratories for Materials Science and Technology, Center for X-ray Analytics CH-8600 Dübendorf Switzerland., Neels A; Empa, Swiss Federal Laboratories for Materials Science and Technology, Center for X-ray Analytics CH-8600 Dübendorf Switzerland., Fortunato G; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles Lerchenfeldstrasse 5 CH-9014 St. Gallen Switzerland rene.rossi@empa.ch., Rossi RM; Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles Lerchenfeldstrasse 5 CH-9014 St. Gallen Switzerland rene.rossi@empa.ch.; ETH Zürich, Department of Health Science and Technology 8092 Zürich Switzerland.
Jazyk:	angličtina
Zdroj:	Nanoscale advances [Nanoscale Adv] 2022 May 23; Vol. 4 (13), pp. 2929-2941. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).
DOI:	10.1039/d2na00201a
Abstrakt:	Electrospun nanofibers have shown great potential as drug vehicles and tissue engineering scaffolds. However, the successful encapsulation of multiple hydrophilic/hydrophobic therapeutic compounds is still challenging. Herein, sodium alginate/poly(ε-caprolactone) core/shell nanofibers were fabricated via water-in-oil emulsion electrospinning. The sodium alginate concentration, water-to-oil ratio, and surfactant concentration were optimized for the maximum stability of the emulsion. The results demonstrated that an increasing water-to-oil ratio results in more deviation from Newtonian fluid and leads to a broader distribution of the fibers' diameters. Moreover, increasing poly(ε-caprolactone) concentration increases loss and storage moduli and increases the diameter of the resulting fibers. The nanofibers' characteristics were investigated by scanning electron microscopy, transmission electron microscopy, confocal laser scanning microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and water contact angle measurements. It was observed that using an emulsion composition of 10% (w/v) PCL and a water-to-oil ratio of 0.1 results in smooth, cylindrical, and uniform core/shell nanofibers with PCL in the shell and ALG in the core. The in vitro cell culture study demonstrated the favorable biocompatibility of nanofibers. Overall, this study provides a promising and trustworthy material for biomedical applications. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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