3D hierarchically porous magnetic molybdenum trioxide@gold nanospheres as a nanogap-enhanced Raman scattering biosensor for SARS-CoV-2.

Autor: Achadu OJ; Research Institute of Green Science and Technology, Shizuoka University 836 Ohya, Suruga-ku Shizuoka 422-8529 Japan park.enoch@shizuoka.ac.jp ojodomo.john.achadu@shizuoka.ac.jp +81-54-238-4887 +81-54-238-3306.; International Institute for Nanocomposites Manufacturing, WMG, University of Warwick CV4 7AL Coventry UK., Nwaji N; International Academy of Optoelectronics at Zhaoqing, South China Normal University Liyuan Street 526238 Guangdong China njemuwa.nwaji@zq-scnu.org., Lee D; Dept. of Chemistry, College of Natural Science, Chungnam National University 99 Daehak-ro, Yuseong-gu Daejeon 34134 Korea., Lee J; Dept. of Chemistry, College of Natural Science, Chungnam National University 99 Daehak-ro, Yuseong-gu Daejeon 34134 Korea., Akinoglu EM; International Academy of Optoelectronics at Zhaoqing, South China Normal University Liyuan Street 526238 Guangdong China njemuwa.nwaji@zq-scnu.org., Giersig M; International Academy of Optoelectronics at Zhaoqing, South China Normal University Liyuan Street 526238 Guangdong China njemuwa.nwaji@zq-scnu.org.; Institute of Fundamental Technological Research, Polish Academy of Sciences 02-106 Warsaw Poland., Park EY; Research Institute of Green Science and Technology, Shizuoka University 836 Ohya, Suruga-ku Shizuoka 422-8529 Japan park.enoch@shizuoka.ac.jp ojodomo.john.achadu@shizuoka.ac.jp +81-54-238-4887 +81-54-238-3306.; Laboratory of Biotechnology, Department of Bioscience, Graduate School of Science and Technology, Shizuoka University 836 Ohya, Suruga-ku Shizuoka 422-8529 Japan.
Jazyk: angličtina
Zdroj: Nanoscale advances [Nanoscale Adv] 2022 Jan 04; Vol. 4 (3), pp. 871-883. Date of Electronic Publication: 2022 Jan 04 (Print Publication: 2022).
DOI: 10.1039/d1na00746g
Abstrakt: The global pandemic of COVID-19 is an example of how quickly a disease-causing virus can take root and threaten our civilization. Nowadays, ultrasensitive and rapid detection of contagious pathogens is in high demand. Here, we present a novel hierarchically porous 3-dimensional magnetic molybdenum trioxide-polydopamine-gold functionalized nanosphere (3D mag-MoO 3 -PDA@Au NS) composed of plasmonic, semiconductor, and magnetic nanoparticles as a multifunctional nanosculptured hybrid. Based on the synthesized 3D mag-MoO 3 -PDA@Au NS, a universal "plug and play" biosensor for pathogens is proposed. Specifically, a magnetically-induced nanogap-enhanced Raman scattering (MINERS) detection platform was developed using the 3D nanostructure. Through a magnetic actuation process, the MINERS system overcomes Raman signal stability and reproducibility challenges for the ultrasensitive detection of SARS-CoV-2 spike protein over a wide dynamic range up to a detection limit of 10 -15 g mL -1 . The proposed MINERS platform will facilitate the broader use of Raman spectroscopy as a powerful analytical detection tool in diverse fields.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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