The Role of Serum Resolvin D1 Levels in Determining the Presence and Prognosis of ST-Segment Elevation Myocardial Infarction.
| Autor: | Karayiğit O; Department of Cardiology, Yozgat City Hospital, Yozgat, Turkey., Nurkoç SG; Department of Cardiology, Yozgat City Hospital, Yozgat, Turkey., Başyiğit F; Department of Cardiology, Ankara City Hospital, Ankara, Turkey., Kızıltunç E; Department of Cardiology, Faculty of Medicine, Gazi University, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Medical principles and practice : international journal of the Kuwait University, Health Science Centre [Med Princ Pract] 2022; Vol. 31 (6), pp. 548-554. Date of Electronic Publication: 2022 Sep 21. |
| DOI: | 10.1159/000527064 |
| Abstrakt: | Background: Resolvin D1 (RvD1) can play a determining role in inflammatory cell migration and reduce the expression of inflammatory cytokines to enhance cardioprotection. The aim of this study was to compare serum RvD1 levels in patients with ST-segment elevation myocardial infarction (STEMI) and individuals with normal coronary arteries (NCAs) and to evaluate the association between serum RvD1 levels and prognostic markers of STEMI. Methods: 140 subjects (88 patients diagnosed with the indication of STEMI and 52 healthy individuals with NCA) were studied. Results: Regression analysis revealed that RvD1 levels were independently associated with STEMI. While RvD1 levels were negatively correlated with high-sensitivity C-reactive protein, pro-brain natriuretic peptide, peak troponin, and Thrombolysis in Myocardial Infarction thrombus grade, they were positively correlated with left ventricular ejection fraction. An RvD1 cut-off value of 5.07 (ng/mL) was effective in predicting STEMI with a sensitivity of 79.5% and specificity of 96.2%. Conclusion: Serum RvD1 levels were found to be lower in the group with STEMI compared to the control group. Levels of RvD1 at admission were associated with poor prognostic markers of STEMI. (© 2022 The Author(s). Published by S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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