HIV-1-Infected CD4 + T Cells Present MHC Class II-Restricted Epitope via Endogenous Processing.

Autor: Addison MM; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Ellis GI; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Leslie GJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and., Zawadzky NB; School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA., Riley JL; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Hoxie JA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and., Eisenlohr LC; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; eisenlc@pennmedicine.upenn.edu.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Jazyk: angličtina
Zdroj: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Sep 01; Vol. 209 (5), pp. 864-873. Date of Electronic Publication: 2022 Aug 05.
DOI: 10.4049/jimmunol.2200145
Abstrakt: HIV-1-specific CD4 + T cells (T CD4+ s) play a critical role in controlling HIV-1 infection. Canonically, T CD4+ s are activated by peptides derived from extracellular ("exogenous") Ags displayed in complex with MHC class II (MHC II) molecules on the surfaces of "professional" APCs such as dendritic cells (DCs). In contrast, activated human T CD4+ s, which express MHC II, are not typically considered for their APC potential because of their low endocytic capacity and the exogenous Ag systems historically used for assessment. Using primary T CD4+ s and monocyte-derived DCs from healthy donors, we show that activated human T CD4+ s are highly effective at MHC II-restricted presentation of an immunodominant HIV-1-derived epitope postinfection and subsequent noncanonical processing and presentation of endogenously produced Ag. Our results indicate that, in addition to marshalling HIV-1-specific immune responses during infection, T CD4+ s also act as APCs, leading to the activation of HIV-1-specific T CD4+ s.
(Copyright © 2022 by The American Association of Immunologists, Inc.)
Databáze: MEDLINE
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