Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.

Autor: Sanderson H; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada., Gray KL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Colombia, Canada., Manuele A; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada., Maguire F; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health & Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Khan A; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada., Liu C; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Mathematics & Statistics, Dalhousie University, Halifax, Nova Scotia, Canada., Navanekere Rudrappa C; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada., Nash JHE; National Microbiology Laboratory, Public Health Agency of Canada, Guelph and Toronto, Ontario, Canada., Robertson J; National Microbiology Laboratory, Public Health Agency of Canada, Guelph and Toronto, Ontario, Canada., Bessonov K; National Microbiology Laboratory, Public Health Agency of Canada, Guelph and Toronto, Ontario, Canada., Oloni M; Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Alcock BP; Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Raphenya AR; Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., McAllister TA; Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada., Peacock SJ; Department of Medicine, Cambridge University, Cambridge, UK., Raven KE; Department of Medicine, Cambridge University, Cambridge, UK., Gouliouris T; Department of Medicine, Cambridge University, Cambridge, UK., McArthur AG; Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, Ontario, Canada., Brinkman FSL; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Colombia, Canada., Fink RC; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada., Zaheer R; Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada., Beiko RG; Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute for Comparative Genomics, Dalhousie University, Halifax, Nova Scotia, Canada.
Jazyk: angličtina
Zdroj: Microbial genomics [Microb Genom] 2022 Sep; Vol. 8 (9).
DOI: 10.1099/mgen.0.000880
Abstrakt: Enterococcus faecium is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 E. faecium genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of E. faecium , type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated with a group of clinical and municipal wastewater genomes that are likely forming a new human-associated ecotype within type A. The evolutionary dynamics of E. faecium make it a highly versatile emerging pathogen, and its ability to acquire, transmit and lose features presents a high risk for the emergence of new pathogenic variants and novel resistance combinations. This study provides a workflow for MGE-centric surveillance of AMR in Enterococcus that can be adapted to other pathogens.
Databáze: MEDLINE