Cerebral Ischemic Reperfusion Injury: Preventative and Therapeutic Strategies.
| Autor: | Gomez F; From the Department of Neurology, University of Missouri School of Medicine, Columbia, MO., El-Ghanem M; Department of Neuroendovascular Surgery, HCA Houston Healthcare, Houston, TX., Feldstein E; Westchester Medical Center, Maria Fareri Children's Hospital, Valhalla, NY., Jagdeo M; Westchester Medical Center, Maria Fareri Children's Hospital, Valhalla, NY., Koul P; Department of Neurology, Northshore-Long Island Jewish Medical Center, Manhasset, NY., Nuoman R; Westchester Medical Center, Maria Fareri Children's Hospital, Valhalla, NY., Gupta G; Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ., Gandhi CD; Westchester Medical Center, Maria Fareri Children's Hospital, Valhalla, NY., Amuluru K; Department of Neurological Surgery, University of Indiana, Indianapolis, IN., Al-Mufti F; Westchester Medical Center, Maria Fareri Children's Hospital, Valhalla, NY. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiology in review [Cardiol Rev] 2023 Nov-Dec 01; Vol. 31 (6), pp. 287-292. Date of Electronic Publication: 2022 Sep 21. |
| DOI: | 10.1097/CRD.0000000000000467 |
| Abstrakt: | Acute ischemic stroke is a leading cause of morbidity and mortality in the United States. Treatment goals remain focused on restoring blood flow to compromised areas. However, a major concern arises after reperfusion occurs. Cerebral ischemic reperfusion injury is defined as damage to otherwise salvageable brain tissue occurring with the reestablishment of the vascular supply to that region. The pool of eligible patients for revascularization continues to grow, especially with the recently expanded endovascular therapeutic window. Neurointensivists should understand and manage complications of successful recanalization. In this review, we examine the pathophysiology, diagnosis, and potential management strategies in cerebral ischemic reperfusion injury. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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