A Randomized Trial to Assess Effectiveness and Safety of a Hyaluronic Acid Filler for Chin Augmentation and Correction of Chin Retrusion.

Autor:	Marcus K; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Moradi A; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Kaufman-Janette J; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Ablon G; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Donofrio L; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Chapas A; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Kazin R; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Rivkin A; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Rohrich RJ; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., Weiss R; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center., George R; From Marcus Facial Plastic Surgery; Moradi M.D.; Skin Research Institute, LLC; Ablon Skin Institute and Research Center; Etre Cosmetic Dermatology and Laser Center; Unionderm; Icon Dermatology and Aesthetics; Westside Aesthetics; Dallas Plastic Surgery Institute; Maryland Dermatology, Laser, Skin & Vein Institute; and Wilmington Dermatology Center.
Jazyk:	angličtina
Zdroj:	Plastic and reconstructive surgery [Plast Reconstr Surg] 2022 Dec 01; Vol. 150 (6), pp. 1240e-1248e. Date of Electronic Publication: 2022 Sep 20.
DOI:	10.1097/PRS.0000000000009733
Abstrakt:	Background: The chin is important for facial appearance, affecting overall balance and harmony of the face. The purpose of this study was to evaluate effectiveness of the hyaluronic acid filler Restylane Defyne for chin augmentation and correction of chin retrusion versus a no-treatment control. Methods: Male and female subjects, aged 22 years or older, with mild to moderate chin retrusion, were randomized 3:1 to the hyaluronic acid filler Restylane Defyne ( n = 107) or no treatment ( n = 33). Assessments included live, blinded evaluations on a validated chin retrusion scale (Galderma Chin Retrusion Scale), aesthetic improvement (Global Aesthetic Improvement Scale), subject-reported FACE-Q Satisfaction with Chin, and safety follow-up. Results: Galderma Chin Retrusion Scale responder rate (≥1 grade improvement) was higher for the hyaluronic acid filler Restylane Defyne (81 percent) than for control (6 percent) ( p < 0.001) at week 12, and remained higher at week 48 (74 percent versus 11 percent; p < 0.001). Aesthetic improvement rates were high throughout the study as reported by investigators (≥96 percent) and subjects (≥85 percent). Subject satisfaction was higher in the hyaluronic acid filler Restylane Defyne group than in the control group at week 12 ( p < 0.001). In the individual FACE-Q scale items, 87 to 98 percent of subjects were satisfied at week 12. Treatment-related adverse events were mild to moderate. Conclusions: The hyaluronic acid filler Restylane Defyne was safe and effective for augmentation of the chin region to improve the chin profile and associated with high aesthetic improvement and subject satisfaction. Effectiveness was sustained throughout 48 weeks. Clinical Question/level of Evidence: Therapeutic, II. (Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Plastic Surgeons. All rights reserved.)
Databáze:	MEDLINE
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