Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.

Autor:	Maguire S; Department of Rheumatology, St James's Hospital, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland., Al-Emadi S; Department of Medicine, Hamad Medical Corporation, Doha, Qatar., Alba P; Rheumatology Unit, Hospital Cordoba, Cordoba, Argentina.; School of Medicine, Universidad Nacional de Cordoba, Cordoba, Argentina., Aguiar MC; Hospital General Agustin O'Horan, Merida, Mexico., Al Lawati T; Department of Rheumatology, Sultan Qaboos University Hospital, Muscat, Oman., Alle G; Department of Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Bermas B; UT Southwestern Medical Center, Dallas, TX, USA., Bhana S; Department of Rheumatology, Crystal Run Healthcare, Middleton, NY, USA., Branimir A; School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.; Division of Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, Zagreb, Croatia., Bulina I; Department of Rheumatology, Paul Stradins Clinical University Hospital, Riga, Latvia.; Department of Internal Diseases, Riga Stradins University, Riga, Latvia., Clowse M; Duke University School of Medicine, Durham, NC, USA., Cogo K; Department of Rheumatology, Hospital Interzonal Luis Guemes, Buenos Aires, Argentina.; Department of Rheumatology, Hospital San Juan De Dios, Buenos Aires, Argentina., Colunga I; Department of Rheumatology, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, Mexico., Cook C; Division of Rheumatology, Massachusetts General Hospital, Allergy & Immunology, Boston, MA, USA., Cortez KJ; Department of Rheumatology, Baguio General Hospital and Medical Center, Baguio City, Philippines., Dao K; UT Southwestern Medical Center, Dallas, TX, USA., Gianfrancesco M; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Gore-Massey M; Lupus Foundation of America Inc., Gossec L; Sorbonne Universite, Paris, France.; Pitie-Salpetriere Hospital, Paris, France., Grainger R; Department of Medicine, University of Otago, Wellington, New Zealand., Hausman J; Department of Pediatric Rheumatology, Boston Children's Hospital, Boston, MA, USA.; Department of Rheumatology and Clinical Immunology, Beth Isreal Deaconess Medical Center, Boston, MA, USA., Hsu TYT; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Hyrich K; Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester, UK.; Department of MSK Research, Manchester Academic Health Science Centre, Manchester, UK.; Department of Biomedical Research, UK and National Institute of Health Research Manchester, Manchester, UK., Isnardi C; Research Unit, Argenitine Society of Rheumatology, Buenos Aires, Argentina., Kawano Y; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA., Kilding R; Department of Rheumatology, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK., Kusevich DA; Department of Rheumatology, Nasonova Research Institute of Rheumatology, Vidnoe, Russia., Lawson-Tovey S; Department of MSK Research, Manchester Academic Health Science Centre, Manchester, UK.; Department of Biomedical Research, UK and National Institute of Health Research Manchester, Manchester, UK.; University of Manchester, Centre for Musculoskeletal Research, Centre for Genetics and Genomics Versus Arthritis, Manchester, UK.; Department of Biomedical Research, Manchester University NHS Foundation Trust, Manchester, UK., Liew J; Boston University School of Medicine, Boston, MA, USA., McCarthy E; Department of Rheumatology, Beaumont Hospital, Dublin, Ireland., Montgumery A; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; VA Medical Center, Department of Health Research, San Francisco, CA, USA., Moyano S; Department of Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Nasir N; Department of Medicine, The Aga Khan University Hospital, Section of Internal Medicine, Karachi, Pakistan., Padjen I; School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.; Division of Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, Zagreb, Croatia., Papagoras C; First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece., Patel NJ; Division of Rheumatology, Massachusetts General Hospital, Allergy & Immunology, Boston, MA, USA., Pera M; Department of Rheumatology, Hospital Angel C Padilla, Tucuman, Argentina., Pisoni C; Rheumatology and Immunology Section, Department of Internal Medicine, CEMIC, Buenos Aires, Argentina., Pons-Estel G, Quiambao AL; Department of Rheumatology, East Avenue Medical Center, Quezon City, Philippines., Quintana R; Research Unit, Argenitine Society of Rheumatology, Buenos Aires, Argentina., Ruderman E; Department of Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sattui S; Department of Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA., Savio V; Rheumatology Unit, Hospital Cordoba, Cordoba, Argentina., Sciascia S; Osedale San Giovanni Bosco, Centro Multidisciplinare de Recerche di Immunopatologia e Documentazione su Malattie Rare (C.M.I.D.), Turin, Italy., Sencarova M; Department of Rheumatology, Univerzitna Nemocnica L Pasteura, Kosice, Slovakia., Morales RS; Centro Regional de Enfermedades Autoinmunes y Reumaticas (GO-CREAR), Rosario, Argentina., Siddique F; Department of Rheumatology, Loyola University Medical Center, Maywood, IL, USA., Sirotich E; Department of Health Research, Evidence and Impact, McMaster University, Hamilton, ON, Canada., Sparks J; Department of Rheumatology and Clinical Immunology, Beth Isreal Deaconess Medical Center, Boston, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA., Strangfeld A; Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany., Sufka P; Healthcare Partners, St Paul, MN, USA., Tanner H; Department of Rheumatology, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.; Royal Brisbane Clinical Unit, University of Queensland, Brisbane, QLD, Australia., Tissera Y; Rheumatology Unit, Hospital Cordoba, Cordoba, Argentina., Wallace Z; Division of Rheumatology, Massachusetts General Hospital, Allergy & Immunology, Boston, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA., Werner ML; Department of Rheumatology, Hospital Nacional de Clinicas, Cordoba, Argentina., Wise L; Keck School of Medicine, University of Southern California, Los Angelos, CA, USA., Worthing AB; Department of Rheumatology, Arthritis and Rheumatism Associates PC, Washington, DC, USA.; Georgetown University Medical Center, Washington, DC, USA., Zell J; Division of Rheumatology, University of Colorado Health, Aurora, Colorado, USA., Zepa J; Department of Rheumatology, Paul Stradins Clinical University Hospital, Latvia, Riga.; School of Medicine, Riga Stradins University, Latvia, Riga., Machado PM; Centre for Rheumatology and Department of Neuromuscular Diseases, University College London, London, UK.; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK.; Department of Rheumatology, Northwick Park Hospital, London, UK., Yazdany J; Division of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Robinson P; Department of Rheumatology, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.; Royal Brisbane Clinical Unit, University of Queensland, Brisbane, QLD, Australia.; Metro North Hospital & Health Service, Herston, QLD, Australia., Conway R; Department of Rheumatology, St James's Hospital, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Apr 03; Vol. 62 (4), pp. 1621-1626.
DOI:	10.1093/rheumatology/keac534
Abstrakt:	Objective: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. Results: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). Conclusions: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy. (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Databáze:	MEDLINE
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