TFLink: an integrated gateway to access transcription factor-target gene interactions for multiple species.

Autor: Liska O; HCEMM-BRC Metabolic Systems Biology Research Group, Temesvári krt. 62, Szeged 6726, Hungary.; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Temesvári krt. 62, Szeged 6726, Hungary.; Department of Genetics, ELTE Eötvös Loránd University, Pázmány P. stny. 1/C, Budapest 1117, Hungary.; Doctoral School of Biology, University of Szeged, Közép fasor 52, Szeged 6726, Hungary., Bohár B; Department of Genetics, ELTE Eötvös Loránd University, Pázmány P. stny. 1/C, Budapest 1117, Hungary.; Earlham Institute, Colney Ln, Norwich NR4 7UZ, UK., Hidas A; Department of Genetics, ELTE Eötvös Loránd University, Pázmány P. stny. 1/C, Budapest 1117, Hungary.; Institute of Aquatic Ecology, Centre for Ecological Research, Eötvös Loránd Research Network (ELKH), Karolina út 29, Budapest 1113, Hungary., Korcsmáros T; Earlham Institute, Colney Ln, Norwich NR4 7UZ, UK.; Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK.; Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK., Papp B; HCEMM-BRC Metabolic Systems Biology Research Group, Temesvári krt. 62, Szeged 6726, Hungary.; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Temesvári krt. 62, Szeged 6726, Hungary., Fazekas D; Department of Genetics, ELTE Eötvös Loránd University, Pázmány P. stny. 1/C, Budapest 1117, Hungary.; Earlham Institute, Colney Ln, Norwich NR4 7UZ, UK., Ari E; HCEMM-BRC Metabolic Systems Biology Research Group, Temesvári krt. 62, Szeged 6726, Hungary.; Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Temesvári krt. 62, Szeged 6726, Hungary.; Department of Genetics, ELTE Eötvös Loránd University, Pázmány P. stny. 1/C, Budapest 1117, Hungary.
Jazyk: angličtina
Zdroj: Database : the journal of biological databases and curation [Database (Oxford)] 2022 Sep 16; Vol. 2022.
DOI: 10.1093/database/baac083
Abstrakt: Analysis of transcriptional regulatory interactions and their comparisons across multiple species are crucial for progress in various fields in biology, from functional genomics to the evolution of signal transduction pathways. However, despite the rapidly growing body of data on regulatory interactions in several eukaryotes, no databases exist to provide curated high-quality information on transcription factor-target gene interactions for multiple species. Here, we address this gap by introducing the TFLink gateway, which uniquely provides experimentally explored and highly accurate information on transcription factor-target gene interactions (∼12 million), nucleotide sequences and genomic locations of transcription factor binding sites (∼9 million) for human and six model organisms: mouse, rat, zebrafish, fruit fly, worm and yeast by integrating 10 resources. TFLink provides user-friendly access to data on transcription factor-target gene interactions, interactive network visualizations and transcription factor binding sites, with cross-links to several other databases. Besides containing accurate information on transcription factors, with a clear labelling of the type/volume of the experiments (small-scale or high-throughput), the source database and the original publications, TFLink also provides a wealth of standardized regulatory data available for download in multiple formats. The database offers easy access to high-quality data for wet-lab researchers, supplies data for gene set enrichment analyses and facilitates systems biology and comparative gene regulation studies. Database URL https://tflink.net/.
(© The Author(s) 2022. Published by Oxford University Press.)
Databáze: MEDLINE
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