Prefrontal cortical response to natural rewards and self-reported anhedonia are associated with greater craving among recently withdrawn patients in residential treatment for opioid use disorder.

Autor: Petrie DJ; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, United States., Knapp KS; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, United States; Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA, United States., Freet CS; Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA, United States., Deneke E; Caron Treatment Centers, Wernersville, PA, United States., Brick TR; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, United States; Institute for Computational and Data Sciences, The Pennsylvania State University, University Park, PA, United States., Cleveland HH; Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, United States., Bunce SC; Department of Psychiatry, The Pennsylvania State University College of Medicine, Hershey, PA, United States. Electronic address: sbunce@pennstatehealth.psu.edu.
Jazyk: angličtina
Zdroj: Brain research bulletin [Brain Res Bull] 2022 Nov; Vol. 190, pp. 32-41. Date of Electronic Publication: 2022 Sep 16.
DOI: 10.1016/j.brainresbull.2022.09.012
Abstrakt: Both anhedonia and craving are common among patients with opioid use disorder (OUD), and are associated with vulnerability to relapse. Although these constructs are theoretically linked relatively few studies have examined them together. In the current study, recently withdrawn patients (N = 71) in residential treatment for prescription OUD underwent a cue reactivity paradigm while being monitored with functional near-infrared spectroscopy (fNIRS). Patients also self-reported symptoms of anhedonia via the Snaith-Hamilton Pleasure Scale (SHAPS), while smartphone-based ecological momentary assessments (EMA) were used to measure craving levels. On average, lower right prefrontal cortex (PFC) activity in response to positive social stimuli was associated with higher craving (β = - 2.87; S.E. = 1.23; p = 0.02). Self-reported anhedonia moderated the association between PFC activity and craving (β = - 1.02; S.E. = 0.48; p = 0.04), such that patients with two or more anhedonic symptoms had a significant and stronger negative association between PFC activation to hedonically positive images and craving, compared to patients with fewer than two anhedonic symptoms, among whom the association was not significant. This finding provides evidence that higher levels of anhedonia among patients in residential treatment for OUD are associated with a stronger link between lower PFC response to positive social experiences and higher levels of craving, potentially increasing overall vulnerability to relapse.
Competing Interests: Declaration of Interest S.C. Bunce owns equity in fNIR Devices, LLC (Potomac, MD).
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: