Systemic Sclerosis Association with Malignancy.

Autor: Lepri G; Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology, AOUC & Scleroderma Unit, Florence, Italy. lepri.gemma@gmail.com., Catalano M; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Bellando-Randone S; Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology, AOUC & Scleroderma Unit, Florence, Italy., Pillozzi S; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Giommoni E; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Giorgione R; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Botteri C; Medical Oncology Unit, Careggi University Hospital, Florence, Italy., Matucci-Cerinic M; Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology, AOUC & Scleroderma Unit, Florence, Italy.; Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Milan, Italy., Antonuzzo L; Medical Oncology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, and Division of Rheumatology, AOUC & Scleroderma Unit, Florence, Italy.
Jazyk: angličtina
Zdroj: Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2022 Dec; Vol. 63 (3), pp. 398-416. Date of Electronic Publication: 2022 Sep 19.
DOI: 10.1007/s12016-022-08930-4
Abstrakt: The association of systemic sclerosis (SSc) and cancer is well known from several decades suggesting common genetic and environmental risk factors involved in the development of both diseases. Immunosuppressive drugs widely used in SSc may increase the risk of cancer occurrence and different SSc clinical and serological features identify patients at major risk to develop malignancy. In this context, among serological features, presence of anti-RNA polymerase III and anti-topoisomerase I autoantibodies seems to increase cancer frequency in SSc patients (particularly lung and breast cancers). Lung fibrosis and a long standing SSc pulmonary involvement have been largely proposed as lung cancer risk factors, and the exposure to cyclophosphamide and an upper gastrointestinal involvement have been traditionally linked to bladder and oesophagus cancers, respectively. Furthermore, immune checkpoint inhibitors used for cancer therapy can induce immune-related adverse events, which are more frequent and severe in patients with pre-existing autoimmune diseases such as SSc. The strong association between SSc and cancer occurrence steers clinicians to carefully survey SSc patients performing periodical malignancy screening. In the present review, the most relevant bilateral relationships between SSc and cancer will be addressed.
(© 2022. The Author(s).)
Databáze: MEDLINE
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