Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration.

Autor:	Matouk AI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., El-Daly M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Habib HA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Senousy S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Naguib Abdel Hafez SM; Department of Pathology, Faculty of Medicine, Minia University, Minya, Egypt., Kasem AW; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minya, Egypt., Almalki WH; Department of Pharmacology and Toxicology, Umm Al-Qura University, Makkah, Saudi Arabia., Alzahrani A; Department of Pharmacology and Toxicology, College of Clinical Pharmacy, ‬AlBaha University, Al Bahah, Saudi Arabia., Alshehri A; Department of Pharmacology and Toxicology, College of Clinical Pharmacy, ‬AlBaha University, Al Bahah, Saudi Arabia., Ahmed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 Aug 30; Vol. 13, pp. 952337. Date of Electronic Publication: 2022 Aug 30 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.952337
Abstrakt:	Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and increases the risk of death. Inflammation and oxidative stress are the main mediators in the pathophysiology of sepsis. Therefore, we investigated the role of menthol, a natural antioxidant, against sepsis-induced liver injury in female Wistar rats. Sepsis was induced by cecal ligation and puncture (CLP). Menthol (100 mg/kg) was given intragastric 2 h after CLP. Blood samples and liver tissues were collected 24 h after surgery. Menthol significantly ( p < 0.05) attenuated the sepsis-induced elevation in serum liver enzymes and improved the hepatic histopathological changes. Menthol treatment significantly ( p < 0.05) decreased hepatic levels of tumor necrosis factor-alpha, malondialdehyde, total nitrite, and cleaved caspase-3. It restored the hepatic levels of superoxide dismutase and reduced glutathione. Additionally, menthol significantly ( p < 0.05) increased hepatic levels of B-cell lymphoma 2 (Bcl-2); an anti-apoptotic factor, and proliferating cell nuclear antigen (PCNA), a biomarker of regeneration and survival. Our results showed the therapeutic potential of menthol against liver injury induced by sepsis. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Matouk, El-Daly, Habib, Senousy, Naguib Abdel Hafez, Kasem, Almalki, Alzahrani, Alshehri and Ahmed.)
Databáze:	MEDLINE
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