Nutritional Status in a Sample of Patients With β-Thalassemia Major.

Autor:	Lidoriki I; First Department of Surgery, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC., Stavrou G; Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC., Schizas D; First Department of Surgery, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC., Frountzas M; First Propaedeutic Department of Surgery, 'Hippocration' General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC., Fotis L; Third Department of Paediatrics, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Athens, GRC., Kapelouzou A; Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, GRC., Kokkota S; Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC., Fyntanidou B; Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC., Kotzampassi K; Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Aug 14; Vol. 14 (8), pp. e27985. Date of Electronic Publication: 2022 Aug 14 (Print Publication: 2022).
DOI:	10.7759/cureus.27985
Abstrakt:	Background: Patients suffering from thalassemia have decreased levels of lean body mass and an increased nutritional risk. To assess the body composition and vitamin D levels of thalassemic patients in relation to nutritional risk. Methods: A total of 67 consecutive adult patients who were diagnosed with thalassemia major and followed a regular blood transfusion scheme were included in this study. Demographic and clinical data were collected for each participant. Blood samples were collected to assess 25-hydroxy-vitamin D (25-OH-D) levels. The assessment of patients' nutritional risk was based on the Malnutrition Universal Screening Tool. Body composition assessment was based on bioelectrical impedance analysis (BIA). Results: Eleven patients (16.4%) and five patients (7.5%) were at moderate and high risk for malnutrition, respectively. Moreover, 86.6% of patients had a low fat-free mass index (FFMI) and 74.6% of patients had a high-fat mass (FM) index. The prevalence of sarcopenic obesity and 25-OH-D deficiency was 64.2% and 92.2%, respectively. Medium and high-risk patients had significantly lower BMI (18.81 ± 1.29 vs 23.90 ± 2.65 kg/m 2 , p<0.001), lower FFM index (12.80 ± 1.38 vs 14.19 ± 1.89 kg/m 2 , p=0.009) and lower FM index (5.97 ± 1.86 vs 9.70 ± 2.70 kg/m 2 , p<0.001) than their low-risk counterparts. Conclusions: Adult patients with β-thalassemia major had low levels of vitamin D and altered body composition, presenting with increased adiposity, low levels of lean body mass, and high rates of sarcopenic obesity. Timely detection of patients at risk could lead to the prioritization of patients who could benefit from nutritional interventions. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Lidoriki et al.)
Databáze:	MEDLINE
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