Long-term consumption of virgin coconut ( Cocos nucifera ) oil diet impairs learning and memory in CD1 mice.

Autor: Bisong SA; Department of Physiology, College of Medical Sciences, University of Calabar, Calabar 540242, Nigeria., Nku CO; Department of Physiology, College of Medical Sciences, University of Calabar, Calabar 540242, Nigeria., Sanya OA; Department of Physiology, College of Medical Sciences, University of Calabar, Calabar 540242, Nigeria., Ita SO; Department of Physiology, University of Uyo, Uyo 520232, Nigeria., Fischer VA; Department of Anatomy, University of Calabar, Calabar 540242, Nigeria., Abuo FE; Department of Physiology, Federal University, Ndufu-Alike Ikwo, Ebonyi State 482131, Nigeria.
Jazyk: angličtina
Zdroj: Chinese herbal medicines [Chin Herb Med] 2020 Aug 15; Vol. 12 (4), pp. 414-420. Date of Electronic Publication: 2020 Aug 15 (Print Publication: 2020).
DOI: 10.1016/j.chmed.2020.03.008
Abstrakt: Objective: Virgin coconut oil (VCO) has been used in the management of dementia in Alzheimer's disease (AD). Therefore, this research investigated the effect of long-term consumption of VCO diet on learning and memory in CD1 mice.
Methods: Thirty male CD1 mice (divided into three groups, n  = 10) were fed with standard rodent chow (control), 5% and 20% VCO diets (respectively) for 28 d. The Morris Water Maze (MWM) test was used to test the effect of VCO on visuo-spatial learning and memory, while the Novel Object Recognition Test (NORT) was used to measure short- and long-term recognition memory.
Results: Learning performance of mice did not differ in the MWM. During the probe trial, duration in the retention quadrant and annulus crossings were lower ( P  < 0.05) in the 5% and 20% VCO diet groups compared to the control diet group, showing that VCO impaired visuo-spatial memory. During the NORT, mice showed more total approaches in the 20% VCO diet group ( P  < 0.05) compared to control and the 5% VCO diet groups during the short-term memory test. During the long-term memory retention test, the total approaches were also higher in the 20% VCO group compared to control and 5% VCO group ( P  > 0.05). The discrimination index was also lower in the 20% VCO group compared to control and 5% VCO diet groups indicating impaired long-term cognitive memory in mice given 20% VCO diet. Histological examination of brains showed damage within the CA1 pyramidal cell layer of the hippocampus in the 20% VCO diet group, in line with the behavioural observations.
Conclusion: Long-term consumption of virgin coconut oil diet impairs memory in mice.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.)
Databáze: MEDLINE
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