Paecilins F-P, new dimeric chromanones isolated from the endophytic fungus Xylaria curta E10, and structural revision of paecilin A.

Autor:	Wei PP; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Ai HL; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Shi BB; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Ye K; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Lv X; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Pan XY; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Ma XJ; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Xiao D; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Li ZH; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China., Lei XX; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 Sep 02; Vol. 13, pp. 922444. Date of Electronic Publication: 2022 Sep 02 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.922444
Abstrakt:	A total of eleven new dimeric chromanones, paecilins F-P ( 2 - 12 ), were isolated from the endophytic fungus Xylaria curta E10, along with four known analogs ( 1 , 13 - 15 ). Their structures and absolute configurations were determined by extensive experimental spectroscopic methods, single-crystal X-ray diffraction, and equivalent circulating density (ECD) calculations. In addition, the structure of paecilin A, which was reported to be a symmetric C8-C8' dimeric pattern, was revised by analysis of the nuclear magnetic resonance (NMR) data, and single-crystal X-ray diffraction. Compound 1 showed antifungal activity against the human pathogenic fungus Candida albicans with a minimum inhibitory concentration of 16 μg/mL, and Compounds 8 and 10 showed antibacterial activity against the gram-negative bacterium Escherichia coli with the same minimum inhibitory concentration of 16 μg/mL. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Wei, Ai, Shi, Ye, Lv, Pan, Ma, Xiao, Li and Lei.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu