Ethanolic extract of Lippia graveolens stem reduce biochemical markers in a murine model with metabolic syndrome.

Autor:	Frías-Zepeda ME; Instituto Politécnico Nacional-CIIDIR Durango, Biotechnology Group, Mexico., Rosales-Castro M; Instituto Politécnico Nacional-CIIDIR Durango, Biotechnology Group, Mexico., Escalona-Cardoso GN; Instituto Politécnico Nacional-ENCB- Ciudad de México, Physiology Department, Mexico., Paniagua-Castro N; Instituto Politécnico Nacional-ENCB- Ciudad de México, Physiology Department, Mexico.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Dec; Vol. 29 (12), pp. 103422. Date of Electronic Publication: 2022 Aug 18.
DOI:	10.1016/j.sjbs.2022.103422
Abstrakt:	Metabolic Syndrome (MetS) is a risk to develop metabolic-chronic degenerative disease, it is important to find natural alternatives to help decrease the risk. Mexican oregano has a traditional use in Mexican food, moreover, has pharmacologic effects that can help to reduce risk the metabolic syndrome. The aim of this work was to determine the effect of Mexican oregano ethanolic extract in metabolic syndrome in murine model. Ethanolic extract of Mexican oregano ( Lippia graveolens ) stem (Ext) had a favorable effect on biochemical markers in a murine model of MetS, induced by injection of monosodium glutamate (MSG). From newborn female mice, two groups were formed: control and the MSG groups, which received a dosage of 2 mg/kg of MSG via subcutaneous injection at the second and fourth postnatal day (PD 2,4), and 4 mg/kg at the PD 6, 8, 10 to induce obesity. On week 13, a part of the MSG group received Ext (group MSG + Ext) at 300 mg/kg, administered orally daily from week 13 to week 18. The results indicated that ethanolic extract of Lippia graveolens stem decreases the percentage of body fat, waist circumference, and body weight gain as well as cholesterol, serum triglyceride concentrations and systolic and diastolic pressure. Insulin and leptin hormone values showed a significant effect with the Ext administration. However, hepatic lipoperoxidation levels of MSG and MSG + Ext groups did not show any statistically significant differences between them, both being higher than the control group. Taking in consideration the results obtained in this study, it is concluded that the administration of Ext had a beneficial effect in the murine model with MetS. This is the first study demonstrating the potential of the polar fraction Lippia graveolens stem in MetS. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 Published by Elsevier B.V. on behalf of King Saud University.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu