Effect of green tea consumption in treatment of mild to moderate depression in Iranian patients living with HIV: A double-blind randomized clinical trial.

Autor: Manshadi Seyed Ali D; Department of Infectious Diseases and Tropical Medicine, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Tehran 11519, Iran., Seyed Alireza M; Department of Infectious Diseases and Tropical Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd 11519, Iran., Mohammad Reza S; Department of Infectious Diseases and Tropical Medicine, Imam-Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Tehran 11519, Iran., Jayran Z; Cognitive Neuroscience Linguistics, Institute for Cognitive Science Studies (ICSS), Tehran 11519, Iran., SeyedAhmad S; Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran 11519, Iran., Shams Ali R; Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran 11519, Iran., Seyed Saeid M; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 11519, Iran., Ali AA; Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran 11519, Iran.
Jazyk: angličtina
Zdroj: Chinese herbal medicines [Chin Herb Med] 2020 Nov 26; Vol. 13 (1), pp. 136-141. Date of Electronic Publication: 2020 Nov 26 (Print Publication: 2021).
DOI: 10.1016/j.chmed.2020.08.002
Abstrakt: Objective: Depression affects people living with HIV (PLWH) compliance leading to poor control infection. Previous observational studies showed an anti-depression effect of green tea extract (GTE). The therapeutic effect of GTE on depression were investigated in PLWH receiving antiretroviral therapy (ART).
Methods: Fifty PLWH on ART with diagnose of mild to moderate of depression, participated in a double-blind, placebo-controlled trial and underwent 12 weeks of treatment with either 400 mg GTE capsules or placebo twice daily. The Hamilton depression scale of patients was measured before, 6 weeks and 12 weeks after treatment in two groups. The primary outcome measure was performed to evaluate the efficacy of GTE in improving depressive symptoms.
Results: The mean of Hamilton score showed a significant difference between the two groups after 12 weeks ( P  = 0.035). Repeated measures ANOVA test showed a significant effect for time × treatment interaction on the Hamilton mean score between the two groups ( P  = 0.000).
Conclusion: It seems the use of GTE capsules in PLWH on ART is safe and could lead to greater and more rapid improvement in depressive symptoms than placebo. Thus it can be considered as an alternative therapy for mild to moderate depression. Further studies with higher sample size and longer follow-up and comparisons with other antidepressive drugs are warranted.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.)
Databáze: MEDLINE
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