Alternative fat: redefining adipocytes for biomanufacturing cultivated meat.

Autor: Sugii S; Bioengineering Systems Division, Institute of Bioengineering and Bioimaging (IBB), A*STAR, 31 Biopolis Way #07-01, Singapore 138669; Current address: Cell Biology and Therapies Division, Institute of Molecular and Cell Biology (IMCB), A*STAR, 61 Biopolis Drive #07-04 Proteos, Singapore 138673; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 8 College Road, Singapore 169857. Electronic address: shigekis@imcb.a-star.edu.sg., Wong CYQ; Bioengineering Systems Division, Institute of Bioengineering and Bioimaging (IBB), A*STAR, 31 Biopolis Way #07-01, Singapore 138669; Current address: Cell Biology and Therapies Division, Institute of Molecular and Cell Biology (IMCB), A*STAR, 61 Biopolis Drive #07-04 Proteos, Singapore 138673., Lwin AKO; Bioengineering Systems Division, Institute of Bioengineering and Bioimaging (IBB), A*STAR, 31 Biopolis Way #07-01, Singapore 138669; Current address: Cell Biology and Therapies Division, Institute of Molecular and Cell Biology (IMCB), A*STAR, 61 Biopolis Drive #07-04 Proteos, Singapore 138673., Chew LJM; Bioengineering Systems Division, Institute of Bioengineering and Bioimaging (IBB), A*STAR, 31 Biopolis Way #07-01, Singapore 138669; Current address: Cell Biology and Therapies Division, Institute of Molecular and Cell Biology (IMCB), A*STAR, 61 Biopolis Drive #07-04 Proteos, Singapore 138673.
Jazyk: angličtina
Zdroj: Trends in biotechnology [Trends Biotechnol] 2023 May; Vol. 41 (5), pp. 686-700. Date of Electronic Publication: 2022 Sep 15.
DOI: 10.1016/j.tibtech.2022.08.005
Abstrakt: Cellular agriculture provides a potentially sustainable way of producing cultivated meat as an alternative protein source. In addition to muscle and connective tissue, fat is an important component of animal meat that contributes to taste, texture, tenderness, and nutritional profiles. However, while the biology of fat cells (adipocytes) is well studied, there is a lack of investigation on how adipocytes from agricultural species are isolated, produced, and incorporated as food constituents. Recently we compiled all protocols related to generation and analysis of adipose progenitors from bovine, porcine, chicken, other livestock and seafood species. In this review we summarize recent developments and present key scientific questions and challenges that need to be addressed in order to advance the biomanufacture of 'alternative fat'.
Competing Interests: Declaration of interests The authors declare that S.S., C.Y.Q.W., A.K.O.L., and L.J.M.C. have filed a PCT patent related to novel adipocytic cell lines and cultivation methods from agricultural species (PCT/SG2022/050482). S.S., C.Y.Q.W., A.K.O.L., and L.J.M.C. are cofounders and shareholders of ImpacFat Pte. Ltd. that was spun out of the said IP.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: