Effect of Clenbuterol on Muscle Activity During Exercise in Standardbred Horses.

Autor: Rankins EM; Equine Science Center, Department of Animal Science, Rutgers -The State University of New Jersey, New Brunswick, NJ., Salem K; Equine Science Center, Department of Animal Science, Rutgers -The State University of New Jersey, New Brunswick, NJ., Manso Filho HC; Departamento de Zootecnia, Universidade Federal Rural de Pernambuco (UFRPE), Recife-PE, Brasil., Malinowski K; Equine Science Center, Department of Animal Science, Rutgers -The State University of New Jersey, New Brunswick, NJ., McKeever KH; Equine Science Center, Department of Animal Science, Rutgers -The State University of New Jersey, New Brunswick, NJ. Electronic address: mckeever@sebs.rutgers.edu.
Jazyk: angličtina
Zdroj: Journal of equine veterinary science [J Equine Vet Sci] 2022 Nov; Vol. 118, pp. 104126. Date of Electronic Publication: 2022 Sep 15.
DOI: 10.1016/j.jevs.2022.104126
Abstrakt: Clenbuterol (β 2 agonist) is a commonly administered bronchodilator in race and performance horses. While long-term administration can alter exercise performance and muscle properties, little is known about its effects on these parameters following short-term administration. A single dose of clenbuterol (0.80 µg/kg) was expected to alter muscle activity of the extensor carpi radialis, semitendinosus, and longissimus dorsi during submaximal exercise. Eight mature Standardbred horses exercised for 2 minutes at 5 m/s on a high-speed treadmill following clenbuterol dosing (clenbuterol) or no dosing (control) in a crossover experimental design. Surface electromyography (sEMG) data were collected continuously from the muscles of interest and processed to determine average rectified value (ARV) and median frequency (MF) of the signal during peak muscle activation (100 ms period) during 15 strides. ARV data were log transformed. Data were analyzed with a mixed model ANOVA with fixed effects of period and treatment and a random effect of horse. No differences (P > .05) in amplitude (ARV) or frequency (MF) of the EMG signal were detected following clenbuterol administration. Thus, a one-time dose of clenbuterol had no statistically detectable effect on muscle activity during submaximal exercise. Further studies should be undertaken to confirm these results and examine the effects of long-term administration on muscle activity during exercise.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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