Targeted chitosan nanoparticles embedded into graphene oxide functionalized with caffeic acid as a potential drug delivery system: New insight into cancer therapy.

Autor: Tousian B; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, PO Box 1419963111, Tehran, Iran., Ghasemi MH; Applied Chemistry Research Group, ACECR-Tehran Organization, PO Box 13145-186, Tehran, Iran., Khosravi AR; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, PO Box 1419963111, Tehran, Iran. Electronic address: khosravi@ut.ac.ir.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Dec 01; Vol. 222 (Pt A), pp. 295-304. Date of Electronic Publication: 2022 Sep 14.
DOI: 10.1016/j.ijbiomac.2022.09.084
Abstrakt: As a novel drug delivery technology, chitosan (CHI) nanoparticles are encapsulated in graphene oxide (GO) with caffeic acid (CA). The nanocarrier technique combines targeted drug delivery with molecular imaging to provide new cancer insights. Attachment of CA, an anticancer agent for controlled drug release, to functionalized graphene oxide (GON) utilizing 3-aminopropyltriethoxysilane (APTES) was followed by encapsulation of GO with folic acid (FA) attached CHI to produce this novel system. FT-IR was used to characterize and confirm the chemical production process. Brunau-Emmet-Teller (BET) analysis was used to validate multi-holes and nanometric dimensions (1-100 nm) and assess their drug administration use. Release and loading tests showed a pH dependence and implied CA hydrogen-bonding in GON. CA encapsulation and loading percentages are 86 % and 67 %, respectively. The acidic environment (pH 5.3) of tumor cells may produce a larger release of CA, and the release rate of CA maintains a constant trend, indicating the drug is released for more than a week (because the release rate has not reached zero). The proposed method provides a potential candidate for a novel drug delivery system in cancer therapy. The resulting nanohybrid system is a new way to combine biodegradable materials, that can be used in biomedical applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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