Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial.

Autor:	de Araújo ÉMR; Universidade de Fortaleza, Programa de Pós-Graduação em Ciências Médicas, Fortaleza, CE, Brazil., Meneses GC; Universidade de Fortaleza, Programa de Pós-Graduação em Ciências Médicas, Fortaleza, CE, Brazil., Carioca AAF; Universidade de Fortaleza, Curso de Nutrição e Programa de Pós-Graduação em Saúde Coletiva, Fortaleza, CE, Brazil., Martins AMC; Universidade Federal do Ceará, Programas de Pós-Graduação em Farmacologia e Ciências Farmacêuticas, Fortaleza, CE, Brazil., Daher EF; Universidade Federal do Ceará, Faculdade de Medicina, Programa de Pós-graduação em Ciências Médicas, Departamento de Medicina Clínica, Fortaleza, CE, Brazil., Silva Junior GB; Universidade de Fortaleza, Programa de Pós-Graduação em Ciências Médicas, Fortaleza, CE, Brazil.; Universidade Federal do Ceará, Faculdade de Medicina, Programa de Pós-graduação em Ciências Médicas, Departamento de Medicina Clínica, Fortaleza, CE, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de nefrologia [J Bras Nefrol] 2023 Apr-Jun; Vol. 45 (2), pp. 152-161.
DOI:	10.1590/2175-8239-JBN-2022-0021en
Abstrakt:	Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. Results: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). Conclusion: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation.
Databáze:	MEDLINE
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