Lactate Dehydrogenase: The Beacon of Hope?

Autor: Pandarathodiyil AK; Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Ramanathan A; Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.; Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia., Garg R; Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Doss JG; Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.; Department of Community Oral Health and Clinical Prevention, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia., Rahman FBA; Faculty of Dentistry, SEGi University, Jalan Teknologi, Kota Damansara, Petaling Jaya, Selangor, Malaysia., Ghani WMN; Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia., Vijayan SP; Faculty of Dentistry, Kusum Devi Sunderlal Dugar Jain Dental College and Hospital, Kolkata, West Bengal, India.
Jazyk: angličtina
Zdroj: Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2022 Jul; Vol. 14 (Suppl 1), pp. S1090-S1092. Date of Electronic Publication: 2022 Jul 13.
DOI: 10.4103/jpbs.jpbs_104_22
Abstrakt: Lactate dehydrogenase enzyme (LDH) helps in the conversion of glucose into pyruvic acid during aerobic glycolysis and is found in the cytoplasm of most cells in the human body. When oxidative stress occurs in the body, LDH may be released extracellularly and its level is usually indicative of the severity of tissue damage. LDH has proved to be an inestimably resourceful marker in early prediction of serious diseases involving extensive tissue or cellular damage. This short communication explores the potential of LDH as a salivary biomarker of cell injury and death.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Journal of Pharmacy and Bioallied Sciences.)
Databáze: MEDLINE
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