Bacterial isolates, antibiogram and outcomes of blood culture proven sepsis in neonates at a tertiary institution in South East Nigeria: a cross-sectional study.

Autor:	Nnamani KO; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Nnamani CP; Department of Family Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi 435101, Nigeria., Iloh KK; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Nigeria., Aghanya IN; Department of Microbiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ushie SN; Department of Microbiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ofiaeli OC; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ezeudu CE; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Onubogu CU; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ugochukwu EF; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Akujobi CN; Department of Microbiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ezechukwu CC; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in infectious disease [Ther Adv Infect Dis] 2022 Sep 08; Vol. 9, pp. 20499361221122479. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).
DOI:	10.1177/20499361221122479
Abstrakt:	Background: Neonatal sepsis (NNS) in developing countries continues to be a diagnostic and management challenge due to the delays in identifying the aetiologic pathogens and antibiograms. Aim: To determine the predominant bacterial isolates, antibiotic susceptibility pattern and outcomes of blood culture proven sepsis in neonates. Methodology: A hospital-based cross-sectional study of 120 neonates admitted into the Special Care Baby Unit (SCBU) of Nnamdi Azikiwe University Teaching Hospital Nnewi with clinical features suggestive of sepsis. A semi-structured questionnaire and proforma were used to record neonatal, maternal and laboratory information. Blood specimens were collected for aerobic culture using Bactenecin (BACTEC)-Ped plus culture system. Antibiotic susceptibility testing was performed using the Kirby Bauer disc diffusion method. Data obtained were analysed using SPSS version 23.0. p value < 0.05 was considered as significant. Results: There were 68 males and 52 females giving a male-to-female ratio of 1.3:1. The median age at admission was 48 h. Staphylococcus aureus 13 (43.3%) was the most common bacteria isolated. The prevalence of blood culture proven sepsis were 25% and 6.7% of the subjects with positive blood culture died. Gram-positive bacteria isolated were sensitive to gentamicin, vancomycin (VA), linezolid and resistant to penicillin. Gram-negative bacteria isolated were sensitive to meropenem (MEM), imipenem (IPM), ciprofloxacin (CIP) and resistant to ceftazidime, ceftriaxone, ampicillin and amoxicillin-clavulanic acid. Conclusion: The most common bacteria isolated causing NNS using BACTEC automated blood culture system was Staphylococcus aureus . The empirical antibiotics considered for use at the study site are gentamycin, VA for Gram-positive organisms and CIP, IPM and MEM for Gram-negative organisms. Some of the participants with positive blood culture died. Therefore, there is a need for regular antibiogram profiles in all hospitals offering neonatal care. Competing Interests: Competing interests: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article. (© The Author(s), 2022.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu