| Autor: |
Wilkinson I; mAbsolve Limited, Oxford, UK., Hale G; mAbsolve Limited, Oxford, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
MAbs [MAbs] 2022 Jan-Dec; Vol. 14 (1), pp. 2123299. |
| DOI: |
10.1080/19420862.2022.2123299 |
| Abstrakt: |
By combining and cross-checking data from the World Health Organization's lists of international nonproprietary names with three other databases, we assembled a dataset of amino acid sequences of 819 antibody-related therapeutics. This enabled the systematic tabulation of 57 different molecular formats and about 90 different constant-region variants (47 for silencing, 14 for enhancement, 8 for modifying binding to FcRn, 13 for heterodimerization, 4 for site-specific modification and 4 for stabilization), as well as the frequencies of different targets and immunoglobulin allotypes. The curated dataset provides a resource for researchers, giving insights into trends in antibody engineering and a guide to the most frequently tested designs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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