Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study.

Autor: Nkeck JR; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon. jrnkeck@gmail.com.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon. jrnkeck@gmail.com., Ida CM; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Koe VN; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Cardiology Department, Yaoundé Central Hospital, Yaoundé, Cameroon., Ndam AWN; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon., Jessica YNC; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Manuella EO; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Charelle BY; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Corine ZZ; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Andrée NA; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Amazia F; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Nkeck JP; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon., Samba EAM; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon., Moor VJA; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.; Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Yaoundé, Cameroon.; Biochemistry Laboratory of the Yaoundé University Hospital Centre, Yaoundé, Cameroon.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2022 Sep 15; Vol. 15 (1), pp. 300. Date of Electronic Publication: 2022 Sep 15.
DOI: 10.1186/s13104-022-06190-1
Abstrakt: Objective: The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensive Cameroonians. This was a prospective cross-sectional study on non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlates it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI).
Results: We found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p = 0.021], which was dependent of triglycerides levels (r = 0.17; p = 0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied; Although being related to atherogenic risk, as reported in literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population.
(© 2022. The Author(s).)
Databáze: MEDLINE
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