The genomic landscape of contemporary western Remote Oceanians.

Autor:	Arauna LR; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France. Electronic address: lrubioar@pasteur.fr., Bergstedt J; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France; Institute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 171 77, Sweden., Choin J; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France; Chair Human Genomics and Evolution, Collège de France, Paris 75005, France., Mendoza-Revilla J; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Harmant C; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France., Roux M; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France; Bioinformatics and Biostatistics Hub, Institut Pasteur, Université Paris Cité, Paris 75015, France., Mas-Sandoval A; Department of Life Sciences, Imperial College London, Ascot SL5 7PY, UK., Lémée L; Institut Pasteur, Biomics Platform, Paris 75015, France., Colleran H; BirthRites Independent Max Planck Research Group, Department of Human Behavior, Ecology, and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany., François A; Langues, Textes, Traitements Informatiques, Cognition (LaTTiCe), UMR 8094, CNRS, Paris 75015, France., Valentin F; MSH Mondes, UMR 8068, CNRS, Nanterre 92023, France., Cassar O; Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Oncogenic Virus Epidemiology and Pathophysiology Unit, Paris 75015, France., Gessain A; Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Oncogenic Virus Epidemiology and Pathophysiology Unit, Paris 75015, France., Quintana-Murci L; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France; Chair Human Genomics and Evolution, Collège de France, Paris 75005, France. Electronic address: quintana@pasteur.fr., Patin E; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris 75015, France. Electronic address: epatin@pasteur.fr.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2022 Nov 07; Vol. 32 (21), pp. 4565-4575.e6. Date of Electronic Publication: 2022 Sep 14.
DOI:	10.1016/j.cub.2022.08.055
Abstrakt:	The Vanuatu archipelago served as a gateway to Remote Oceania during one of the most extensive human migrations to uninhabited lands ∼3,000 years ago. Ancient DNA studies suggest an initial settlement by East Asian-related peoples that was quickly followed by the arrival of Papuan-related populations, leading to a major population turnover. Yet there is uncertainty over the population processes and the sociocultural factors that have shaped the genomic diversity of ni-Vanuatu, who present nowadays among the world's highest linguistic and cultural diversity. Here, we report new genome-wide data for 1,433 contemporary ni-Vanuatu from 29 different islands, including 287 couples. We find that ni-Vanuatu derive their East Asian- and Papuan-related ancestry from the same source populations and descend from relatively synchronous, sex-biased admixture events that occurred ∼1,700-2,300 years ago, indicating a peopling history common to the whole archipelago. However, East Asian-related ancestry proportions differ markedly across islands, suggesting that the Papuan-related population turnover was geographically uneven. Furthermore, we detect Polynesian ancestry arriving ∼600-1,000 years ago to Central and South Vanuatu in both Polynesian-speaking and non-Polynesian-speaking populations. Last, we provide evidence for a tendency of spouses to carry similar genetic ancestry, when accounting for relatedness avoidance. The signal is not driven by strong genetic effects of specific loci or trait-associated variants, suggesting that it results instead from social assortative mating. Altogether, our findings provide an insight into both the genetic history of ni-Vanuatu populations and how sociocultural processes have shaped the diversity of their genomes. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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