Drug discovery research in Ghana, challenges, current efforts, and the way forward.

Autor: Amewu RK; Department of Chemistry, University of Ghana, Legon-Accra, Ghana., Amoateng P; Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana., Arthur PK; Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon- Accra, Ghana., Asare P; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Asiamah I; Department of Chemistry, School of Physical Sciences, University of Cape Coast, Cape Coast, Ghana., Boamah D; Department of Microbiology, Centre for Plant Medicine, Mampong-Akuapem, Ghana., Darko Otchere I; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Dzidzor Amengor C; Department of Pharmaceutical Chemistry, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana., Ekuadzi E; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana., Chibale K; Holistic Drug Discovery and Development (H3D) Centre at the University of Cape Town (UCT), Rondebosch, South Africa., Farrell SJ; Wellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom., Appiah-Oppong R; Department of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Osei-Safo D; Department of Chemistry, University of Ghana, Legon-Accra, Ghana., David Read K; Wellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom., Hugh Gilbert I; Wellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom., Yeboah-Manu D; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Sep 15; Vol. 16 (9), pp. e0010645. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).
DOI: 10.1371/journal.pntd.0010645
Abstrakt: We have a long-term vision to develop drug discovery research capacity within Ghana, to tackle unmet medical needs in Ghana and the wider West African region. However, there are several issues and challenges that need to be overcome to enable this vision, including training, human resource, equipment, infrastructure, procurement, and logistics. We discuss these challenges from the context of Ghana in this review. An important development is the universities and research centres within Ghana working together to address some of these challenges. Therefore, while there is a long way to go to fully accomplish our vision, there are encouraging signs.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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