Preterm postnatal complications and risk of attention-deficit/hyperactivity disorder.

Autor: Tso WW; State Key Laboratory of Brain & Cognitive Sciences, University of Hong Kong, Hong Kong, China.; Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Ho FKW; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Coghill D; Departments of Paediatrics and Psychiatry, Faculty of Medicine, Dentistry and Health Science, University of Melbourne, Melbourne, VIC, Australia.; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Parkville, VIC, Australia., Lee TM; State Key Laboratory of Brain & Cognitive Sciences, University of Hong Kong, Hong Kong, China.; Laboratory of Neuropsychology and Human Neuroscience, Department of Psychology, The University of Hong Kong, Hong Kong, China., Wang Y; Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Lee SL; Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Wong MS; Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Yam JCS; Department of Ophthalmology, Hong Kong Children's Hospital, Hong Kong, China.; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China., Wong ICK; Research Department of Practice and Policy, UCL School of Pharmacy, London, UK.; Centre for Safe Medication Practice, Departments of Paediatrics and Research, Department of Pharmacology & Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China., Ip P; Department of Paediatrics & Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Jazyk: angličtina
Zdroj: Developmental medicine and child neurology [Dev Med Child Neurol] 2023 Mar; Vol. 65 (3), pp. 358-366. Date of Electronic Publication: 2022 Sep 15.
DOI: 10.1111/dmcn.15401
Abstrakt: Aim: To investigate the association between the risk of attention-deficit/hyperactivity disorder (ADHD) and preterm birth and determine how postnatal complications in children born preterm is associated with the risk of ADHD.
Method: This population-based cohort study used data from the Hong Kong electronic medical records. We followed 359 614 children (48% female; 6-17 years old, mean 11 years 7 months, SD 3 years 2 months) born in public hospitals in Hong Kong from 1st January 2004 to 31st December 2014 and collected medical records and demographic details for mothers and children until 11th November 2020.
Results: The risk of ADHD was 4.0% in children born at term and 5.1% in children born preterm. The odds ratio for ADHD was 2.08 (95% confidence interval [CI] 1.64-2.64) for children born extremely preterm, 1.64 (95% CI 1.46-1.85) for children born very preterm, and 1.15 (95% CI 1.08-1.23) for children born late preterm. Among preterm postnatal complications, only early respiratory disease, retinopathy of prematurity (ROP), and intraventricular haemorrhage were significant predictors of ADHD after controlling for preterm birth, other risk factors, and sociodemographic variables. The excess risk of ADHD among children born very preterm or late preterm could be partly explained by respiratory disease. ROP partially mediated the risk of ADHD in children born very preterm.
Interpretation: Children born preterm in all subcategories, from extremely preterm to late preterm, have increased risk of ADHD. Early respiratory infection partially mediates the risk of ADHD in children born preterm.
(© 2022 Mac Keith Press.)
Databáze: MEDLINE
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