Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1- 13 C-Pyruvate-d 3 .

Autor: Hune T; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Mamone S; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Schroeder H; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Jagtap AP; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Sternkopf S; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Stevanato G; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Korchak S; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany., Fokken C; Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany., Müller CA; German Cancer Consortium (DKTK), partner site Freiburg, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.; Division of Medical Physics, Department of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site Freiburg, Killianstr. 5a, Freiburg, 79106, Germany., Schmidt AB; German Cancer Consortium (DKTK), partner site Freiburg, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.; Division of Medical Physics, Department of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), partner site Freiburg, Killianstr. 5a, Freiburg, 79106, Germany.; Integrative Biosciences (Ibio), Department of Chemistry, Karmanos Cancer Institute (KCI), Wayne State University, 5101 Cass Ave, 48202, Detroit, MI, USA., Becker D; Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany., Glöggler S; NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077, Göttingen, Germany.; Center for Biostructural Imaging of Neurodegeneration of the University Medical Center Göttingen, Von-Siebold-Str. 3A, 37075, Göttigen, Germany.
Jazyk: angličtina
Zdroj: Chemphyschem : a European journal of chemical physics and physical chemistry [Chemphyschem] 2023 Jan 17; Vol. 24 (2), pp. e202200615. Date of Electronic Publication: 2022 Oct 26.
DOI: 10.1002/cphc.202200615
Abstrakt: The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral areas of high metabolic activity. Herein, we demonstrate the feasibility of metabolic tumor imaging using signal-enhanced 1- 13 C-pyruvate-d 3 , which is rapidly enhanced via para-hydrogen, and thus, the signal is amplified by several orders of magnitudes in less than a minute. Using as a model, human melanoma xenografts injected with signal-enhanced 1- 13 C-pyruvate-d3, we show that the conversion of pyruvate into lactate can be monitored along with its kinetics, which could pave the way for rapidly detecting and monitoring changes in tumor metabolism.
(© 2022 The Authors. ChemPhysChem published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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