Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications.

Autor: Eivazzadeh-Keihan R; Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran., Sadat Z; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Aghamirza Moghim Aliabadi H; Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran., Ganjali F; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Kashtiaray A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran., Salimi Bani M; Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran., Komijani S; Biotechnology Research Center, Pasteur Institute of Iran, No.358, 12 Farvardin St., Tehran, 1316943551, Iran.; Department of Biotechnology School of Biology, Alzahra University, Tehran, Iran., Ahadian MM; Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran., Salehpour N; Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran., Ahangari Cohan R; Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran., Maleki A; Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. maleki@iust.ac.ir.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Sep 14; Vol. 12 (1), pp. 15431. Date of Electronic Publication: 2022 Sep 14.
DOI: 10.1038/s41598-022-19511-y
Abstrakt: In this study, the main focus was on designing and synthesizing a novel magnetic nanobiocomposite and its application in hyperthermia cancer treatment. Regarding this aim, sodium alginate (SA) hydrogel with CaCl 2 cross-linker formed and modified by silk fibroin (SF) natural polymer and halloysite nanotubes (HNTs), followed by in situ Fe 3 O 4 magnetic nanoparticles preparation. No important differences were detected in red blood cells (RBCs) hemolysis, confirming the high blood compatibility of the treated erythrocytes with this nanobiocomposite. Moreover, the synthesized SA hydrogel/SF/HNTs/Fe 3 O 4 nanobiocomposite does not demonstrate toxicity toward HEK293T normal cell line after 48 and 72 h. The anticancer property of SA hydrogel/SF/HNTs/Fe 3 O 4 nanobiocomposites against breast cancer cell lines was corroborated. The magnetic saturation of the mentioned magnetic nanobiocomposite was 15.96 emu g -1 . The specific absorption rate (SAR) was measured to be 22.3 W g -1 by applying an alternating magnetic field (AMF). This novel nanobiocomposite could perform efficiently in the magnetic fluid hyperthermia process, according to the obtained results.
(© 2022. The Author(s).)
Databáze: MEDLINE
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