Diagnostic work-up of urinary tract infections in pregnancy: study protocol of a prospective cohort study.

Autor:	Werter DE; Department of Obstetrics and Gynaecology, University of Amsterdam, Amsterdam, The Netherlands d.e.werter@amsterdamumc.nl., Kazemier BM; Department of Obstetrics and Gynaecology, University of Amsterdam, Amsterdam, The Netherlands., van Leeuwen E; Department of Obstetrics and Gynaecology, Amsterdam University Medical Centres, Duivendrecht, The Netherlands., de Rotte MCFJ; Department of Clinical Chemistry, University of Amsterdam, Amsterdam, The Netherlands., Kuil SD; Department of Microbiology, University of Amsterdam, Amsterdam, The Netherlands., Pajkrt E; Obstetrics and Gynaecology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands., Schneeberger C; Department of Microbiology, Amsterdam UMC-Locatie AMC, Amsterdam, The Netherlands.; Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2022 Sep 14; Vol. 12 (9), pp. e063813. Date of Electronic Publication: 2022 Sep 14.
DOI:	10.1136/bmjopen-2022-063813
Abstrakt:	Introduction: Symptoms of urinary tract infections in pregnant women are often less specific, in contrast to non-pregnant women where typical clinical symptoms of a urinary tract infection are sufficient to diagnose urinary tract infections. Moreover, symptoms of a urinary tract infection can mimic pregnancy-related symptoms, or symptoms of a threatened preterm birth, such as contractions. In order to diagnose or rule out a urinary tract infection, additional diagnostic testing is required.The diagnostic accuracy of urine dipstick analysis and urine sediment in the diagnosis of urinary tract infections in pregnant women has not been ascertained nor validated. Methods and Analysis: In this single-centre prospective cohort study, pregnant women (≥16 years old) with a suspected urinary tract infection will be included. The women will be asked to complete a short questionnaire regarding complaints, risk factors for urinary tract infections and baseline characteristics. Their urine will be tested with a urine dipstick, urine sediment and urine culture. The different sensitivities and specificities per test will be assessed. Our aim is to evaluate and compare the diagnostic accuracy of urine dipstick analysis and urine sediment in comparison with urine culture (reference test) in pregnant women. In addition, we will compare these tests to a predefined 'true urinary tract infection', to distinguish between a urinary tract infection and asymptomatic bacteriuria. Ethics and Dissemination: Approval was requested from the Medical Ethics Review Committee of the Academic Medical Centre; an official approval of this study by the committee was not required. The outcomes of this study will be published in a peer-reviewed journal. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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