| Autor: |
Wheeler AW, Henderson DC, Youlten LJ, Al-Janabi II, Hickman BE, Taylor IH, Moran DM |
| Jazyk: |
angličtina |
| Zdroj: |
International archives of allergy and applied immunology [Int Arch Allergy Appl Immunol] 1987; Vol. 83 (4), pp. 354-8. |
| DOI: |
10.1159/000234368 |
| Abstrakt: |
An acid-insoluble, methacrylic acid, methyl methacrylate copolymer (Eudragit L-100) was used to give an enteric coating to a grass pollen extract in order to protect it against gastric degradation. Substantial protection against the degradative effects of simulated gastric secretion was demonstrated using this preparation which was well tolerated by grass pollen-allergic volunteers. The enteric-coated allergen induced a greater secondary antibody response than did an aqueous presentation when administered orally to guinea pigs which had been primed previously by subcutaneous injection. This result indicates that an effective hyposensitisation regimen could consist of a short series of initial parenteral injections, followed by an oral course of the protected allergen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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