The Impact of SARS-CoV-2 Variants on the Clinical Phenotype and Severity of Multisystem Inflammatory Syndrome in Children in South Africa.

Autor:	Abraham DR; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa., Butters C; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa., Abdulbari Yunis N; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa., Lishman J; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa., Scott C; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.; Clinical Research Centre, University of Cape Town, Cape Town, South Africa., van der Zalm MM; Desmond Tutu TB Centre, Department of Pediatrics and Child Health, Stellenbosch University, Cape Town, South Africa., Zühlke L; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.; South African Medical Research Council, Cape Town, South Africa.; Cape Heart Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa., Rabie H; From the Department of Pediatrics and Child Health, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa., Webb K; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.; Crick African Network, Francis Crick Institute, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2022 Dec 01; Vol. 41 (12), pp. e510-e512. Date of Electronic Publication: 2022 Sep 05.
DOI:	10.1097/INF.0000000000003691
Abstrakt:	The effects of SARS-CoV-2 variants on disease phenotype and severity of multisystem inflammatory syndrome in children (MIS-C) are unknown. We compared the clinical phenotype of MIS-C in 129 South African children across four distinct (Ancestral type, Beta, Delta, and Omicron) variant-driven waves and found that MIS-C remains a severe disease with a stable clinical presentation, regardless of variant. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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