Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome.
Autor: | Laroui A; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Galarneau L; Department of Medical Physics, McGill University Health Center, Montreal, QC, Canada., Abolghasemi A; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Benachenhou S; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Plantefève R; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Bouchouirab FZ; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Lepage JF; Department of Paediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada., Corbin F; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada., Çaku A; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, Canada. Artuela.S.Caku@USherbrooke.ca. |
---|---|
Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2022 Sep 13; Vol. 12 (1), pp. 15386. Date of Electronic Publication: 2022 Sep 13. |
DOI: | 10.1038/s41598-022-19476-y |
Abstrakt: | High plasma matrix metalloproteases-9 (MMP-9) levels have been reported in Fragile X Syndrome in a limited number of animal and human studies. Since the results obtained are method-dependent and not directly comparable, the clinical utility of MMP-9 measurement in FXS remains unclear. This study aimed to compare quantitative gel zymography and ELISA and to determine which method better discriminates abnormal MMP-9 levels of individuals with FXS from healthy controls and correlates with the clinical profile. The active and total forms of MMP-9 were quantified respectively, by gel zymography and ELISA in a cohort of FXS (n = 23) and healthy controls (n = 20). The clinical profile was assessed for the FXS group using the Aberrant Behavior Checklist FXS adapted version (ABC-C (© 2022. The Author(s).) |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |