Azanza garckeana ameliorates Bisphenol A-induced reproductive toxicities in rabbit bucks.

Autor: Itodo JI; Department of Animal Science, Federal University Lafia, Nasarawa State, Nigeria. Electronic address: iyojojoy@gmail.com., Rekwot PI; National Animal Production Research Institute, Ahmadu Bello University Zaria, Nigeria., Aluwong T; Department of Theriogenology and Production, Ahmadu Bello University Zaria, Nigeria., Allam L; Department of Veterinary Physiology, Ahmadu Bello University Zaria, Nigeria., Olutimilehin Jolayemi K; Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University Zaria, Nigeria., Kyari S; Department of Veterinary Entomology and Protozoology, Ahmadu Bello University Zaria, Nigeria., Abah KO; Department of Reproduction and Clinic of Farm Animals, Wroclaw University of Environmental and Life Sciences, Poland., Ibrahim S; Department of Animal Science, Federal University of Kashere, Gombe State, Nigeria., Dogara MU; Department of Animal Science, Federal University Lafia, Nasarawa State, Nigeria., Yusuf AT; Department of Agricultural Economics and Extension, Federal University Lafia, Nasarawa State, Nigeria., Musa MM; Department of Animal Science, Federal University Lafia, Nasarawa State, Nigeria., Mundi HL; Department of Animal Science, Federal University Lafia, Nasarawa State, Nigeria., Abdullahi HR; Department of Animal Science, Federal University Lafia, Nasarawa State, Nigeria.
Jazyk: angličtina
Zdroj: Theriogenology [Theriogenology] 2022 Oct 15; Vol. 192, pp. 150-165. Date of Electronic Publication: 2022 Aug 21.
DOI: 10.1016/j.theriogenology.2022.08.023
Abstrakt: This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20-2.00 kg and aged 10-18 months. They were randomly divided into four groups of seven bucks each, group A was administered distilled water (1.5 mL) daily for 12 weeks, group B was administered Bisphenol A (100 mg/kg) for 5 consecutive days in a week for a period of 12 weeks, group C was administered Azanza garckeana (500 mg/kg) daily for 12 weeks and group D was pre-dosed with Bisphenol A (100 mg/kg) for 5 consecutive days in a week over 6 weeks period followed by Azanza garckeana (500 mg/kg) daily for another 6 weeks. Mean testicular weights differed significantly (p < 0.05) between group B (4.4 ± 0.23) when compared with groups A (8.0 ± 0.06), C (8.7 ± 0.19) and D (7.1 ± 0.18). There were significant differences (p < 0.05) in the mean reaction time, spermiogram, testosterone, follicle stimulating hormone, luteinising hormone and sperm DNA fragmentation index between Bisphenol A-exposed groups and treatment groups. On histopathology, there was testicular vacuolization, interstitial hemorrhage, reduction in spermatogenic cells following Bisphenol A exposure. There were layers of dense basophilic cells in the pineal and pituitary parenchymas. In conclusion, Bisphenol A has negative effects on reproduction but administration of Azanza garckeana may possess some therapeutic properties that can ameliorate such adverse effects.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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