Risk of Colorectal Cancer and Colorectal Cancer Mortality Beginning Ten Years after a Negative Colonoscopy, among Screen-Eligible Adults 76 to 85 Years Old.

Autor:	Dalmat RR; Department of Epidemiology, University of Washington, Seattle, Washington., Ziebell RA; Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Kamineni A; Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Phipps AI; Department of Epidemiology, University of Washington, Seattle, Washington.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Weiss NS; Department of Epidemiology, University of Washington, Seattle, Washington.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Breslau ES; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland., Corley DA; Division of Research, Kaiser Permanente Northern California, Oakland, California.; Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, San Francisco, California., Green BB; Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Halm EA; Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey., Levin TR; Division of Research, Kaiser Permanente Northern California, Oakland, California.; Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, San Francisco, California., Schottinger JE; Kaiser Permanente Bernard J Tyson School of Medicine, Department of Health Systems Science, Pasadena, California., Chubak J; Department of Epidemiology, University of Washington, Seattle, Washington.; Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Jan 09; Vol. 32 (1), pp. 37-45.
DOI:	10.1158/1055-9965.EPI-22-0581
Abstrakt:	Background: Few empirical data are available to inform older adults' decisions about whether to screen or continue screening for colorectal cancer based on their prior history of screening, particularly among individuals with a prior negative exam. Methods: Using a retrospective cohort of older adults receiving healthcare at three Kaiser Permanente integrated healthcare systems in Northern California (KPNC), Southern California (KPSC), and Washington (KPWA), we estimated the cumulative risk of colorectal cancer incidence and mortality among older adults who had a negative colonoscopy 10 years earlier, accounting for death from other causes. Results: Screen-eligible adults ages 76 to 85 years who had a negative colonoscopy 10 years earlier were found to be at a low risk of colorectal cancer diagnosis, with a cumulative incidence of 0.39% [95% CI, 0.31%-0.48%) at 2 years that increased to 1.29% (95% CI, 1.02%-1.61%) at 8 years. Cumulative mortality from colorectal cancer was 0.04% (95% CI, 0.02%-0.08%) at 2 years and 0.46% (95% CI, 0.30%-0.70%) at 8 years. Conclusions: These low estimates of cumulative colorectal cancer incidence and mortality occurred in the context of much higher risk of death from other causes. Impact: Knowledge of these results could bear on older adults' decision to undergo or not undergo further colorectal cancer screening, including choice of modality, should they decide to continue screening. See related commentary by Lieberman, p. 6. (©2022 American Association for Cancer Research.)
Databáze:	MEDLINE
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