Phylogeography and genomic analysis of SARS-CoV-2 delta variant in Morocco.

Autor: El Mazouri S; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Bendani H; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Boumajdi N; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Aanniz T; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Kandoussi I; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Amzazi S; Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco., Belyamani L; Emergency Department, Military Hospital Mohammed V, Rabat Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Ibrahimi A; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco., Ouadghiri M; Laboratory of Biotechnology, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco. m.ouadghiri@um5r.ac.ma.
Jazyk: angličtina
Zdroj: Journal of infection in developing countries [J Infect Dev Ctries] 2022 Aug 30; Vol. 16 (8), pp. 1258-1268. Date of Electronic Publication: 2022 Aug 30.
DOI: 10.3855/jidc.16513
Abstrakt: Introduction: Since the COVID-19 pandemic began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously evolved with many variants of concern emerging across the world.
Methodology: In order to monitor the evolution of these variants in Morocco, we analyzed a total of 2130 genomes of the delta variant circulating around the world. We also included 164 Moroccan delta variant sequences in our analysis.
Results: Our findings suggest at least four introductions from multiple international sources and a rise of a dominant delta sub-lineage AY.33 in Morocco. Moreover, we report three mutations in the N-terminal domain of the S protein specific to the Moroccan AY.33 isolates, T29A, T250I and T299I. The effect of these mutations on the secondary structure and the dynamic behavior of the S protein N-terminal domain was further determined.
Conclusions: We conclude that these mutations might have functional consequences on the S protein of SARS-CoV-2.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2022 Safae El Mazouri, Houda Bendani, Nasma Boumajdi, Tarik Aanniz, Ilham Kandoussi, Saaid Amzazi, Lahcen Belyamani, Azeddine Ibrahimi, Mouna Ouadghiri.)
Databáze: MEDLINE
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