Proteomic changes associated with racial background and sepsis survival outcomes.

Autor: Kapp KL; Department of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA.; The Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 32732, USA. rena.as.robinson@vanderbilt.edu., Arul AB; Department of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA., Zhang KC; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA., Du L; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.; Vanderbilt Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Yende S; The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Clinical and Translational Science, University of Pittsburgh, PA, 15261, USA., Kellum JA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA., Angus DC; The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Clinical and Translational Science, University of Pittsburgh, PA, 15261, USA., Peck-Palmer OM; The Clinical Research, Investigation, and Systems Modeling of Acute Illnesses (CRISMA) Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.; Department of Clinical and Translational Science, University of Pittsburgh, PA, 15261, USA.; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Robinson RAS; Department of Chemistry, Vanderbilt University, 5423 Stevenson Center, Nashville, TN, 37235, USA.; The Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, 32732, USA. rena.as.robinson@vanderbilt.edu.
Jazyk: angličtina
Zdroj: Molecular omics [Mol Omics] 2022 Dec 05; Vol. 18 (10), pp. 923-937. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.1039/d2mo00171c
Abstrakt: Intra-abdominal infection is a common cause of sepsis, and intra-abdominal sepsis leads to ∼156 000 U.S. deaths annually. African American/Black adults have higher incidence and mortality rates from sepsis compared to Non-Hispanic White adults. A limited number of studies have traced survival outcomes to molecular changes; however, these studies primarily only included Non-Hispanic White adults. Our goal is to better understand molecular changes that may contribute to differences in sepsis survival in African American/Black and Non-Hispanic White adults with primary intra-abdominal infection. We employed discovery-based plasma proteomics of patient samples from the Protocolized Care for Early Septic Shock (ProCESS) cohort ( N = 107). We identified 49 proteins involved in the acute phase response and complement system whose expression levels are associated with both survival outcome and racial background. Additionally, 82 proteins differentially-expressed in survivors were specific to African American/Black or Non-Hispanic White patients, suggesting molecular-level heterogeneity in sepsis patients in key inflammatory pathways. A smaller, robust set of 19 proteins were in common in African American/Black and Non-Hispanic White survivors and may represent potential universal molecular changes in sepsis. Overall, this study identifies molecular factors that may contribute to differences in survival outcomes in African American/Black patients that are not fully explained by socioeconomic or other non-biological factors.
Databáze: MEDLINE
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