Association between chemosensory dysfunctions and inflammatory biomarkers in patients with SARS-CoV-2 infection: a systematic review and meta-analysis.

Autor: de Melo EGM; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Andrade RM; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., de Abreu de Vasconcellos SJ; Tiradentes University, Aracaju, Sergipe, Brazil., Dos Santos PL; Graduate Program in Applied Health Sciences, Federal University of Sergipe, Lagarto, Sergipe, Brazil.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Tanajura DM; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil., Quintans-Júnior LJ; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.; Laboratory of Neurosciences and Pharmacological Assays, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Quintans JSS; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil.; Laboratory of Neurosciences and Pharmacological Assays, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil., Martins-Filho PR; Graduate Program in Dentistry, Hospital Universitário, Federal University of Sergipe, Rua Cláudio Batista, s/n. Sanatório, Aracaju, Sergipe, CEP: 49060-100, Brazil. prmartinsfh@gmail.com.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil. prmartinsfh@gmail.com.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil. prmartinsfh@gmail.com.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2022 Dec; Vol. 30 (6), pp. 2079-2087. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1007/s10787-022-01066-z
Abstrakt: Background: There is evidence that chemosensory dysfunctions, including smell and taste disorders, are common findings in patients with SARS-CoV-2 infection. However, the underlying biological mechanisms and the role of inflammatory markers are still poorly understood.
Aim: To investigate the inflammatory biomarkers levels in patients with COVID-19 presenting chemosensory dysfunctions.
Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A systematic literature search was performed from January 1, 2020, to May 12, 2022. Observational studies that provided data on hematological, biochemical, infection-related indices and cellular immunity, and coagulation function in patients with COVID-19 experiencing smell and/or taste disorders were considered eligible. Effect sizes were reported as standardized mean difference (SMD) with 95% confidence intervals (CI). A negative effect size indicated that the inflammatory biomarker levels were lower among patients with chemosensory dysfunctions.
Results: Eleven studies were included. Patients with chemosensory disturbances had lower levels of leukocytes (SMD - 0.18, 95% CI - 0.35 to - 0.01, p = 0.04), lactate dehydrogenase (SMD - 0.45, 95% CI - 0.82 to - 0.09, p = 0.01), IL-6 (SMD - 0.25, 95% CI - 0.44 to - 0.06, p < 0.01), and C-reactive protein (SMD - 0.33, 95% CI - 0.58 to - 0.08, p < 0.01) than patients without chemosensory disturbances.
Conclusion: Patients with SARS-CoV-2 infection who have olfactory and gustatory disorders have a lower inflammatory response than patients who do not have chemosensory alterations. The presence of these symptoms may indicate a more favorable clinical course for COVID-19.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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