High-refined carbohydrate diet alters different metabolic functions in female rats.

Autor: Zanol JF; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Niño OMS; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil; Faculty of Human Sciences and Education, Universidad de los Llanos, Villavicencio-Meta, Colombia., da Costa CS; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Zimerman J; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Silva NP; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Oliveira TM; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Maas EMSWD; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Dos Santos FCF; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil., Miranda-Alves L; Experimental Endocrinology Research, Development and Innovation Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Postgraduate Program in Endocrinology, School of Medicine, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, Ilha do Governador, Cidade Universitária, RJ, UFRJ, Brazil., Graceli JB; Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil. Electronic address: jbgraceli@gmail.com.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2022 Dec 01; Vol. 558, pp. 111774. Date of Electronic Publication: 2022 Sep 09.
DOI: 10.1016/j.mce.2022.111774
Abstrakt: A diet containing refined carbohydrate (HCD) caused obesity and white adipose tissue (WAT) abnormalities, but it is unclear if HCD is linked with other metabolic dysfunctions in female models. Thus, we assessed whether HCD results in WAT, pancreas, liver, skeletal muscle (SM) and thyroid (TH) abnormalities in female rats. Female rats were fed with HCD for 15 days and metabolic morphophysiology, inflammation, oxidative stress (OS), and fibrosis markers were assessed. HCD rats presented large adipocytes, hyperleptinemia, and WAT OS. HCD caused irregular glucose metabolism, low insulin levels, and large pancreatic isle. Granulomas, reduced glycogen, and OS were observed in HCD livers. HCD caused hypertrophy and increased in glycogen in SM. HCD caused irregular TH morphophysiology, reduced colloid area and high T3 levels. In all selected tissues, inflammation and fibrosis were observed in HCD rats. Collectively, these data suggest that the HCD impairs metabolic function linked with irregularities in WAT, pancreas, liver, SM and TH in female rats.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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