Is asthma control more than just an absence of symptoms? An expert consensus statement.

Autor: Canonica GW; Humanitas University, Personalized Medicine Asthma & Allergy Clinic-Humanitas Research Hospital IRCCS, Milan, Italy. Electronic address: canonica.gw@gmail.com., Spanevello A; Dipartimento di Medicina e Chirurgia, Università degli Studi dell'Insubria, Varese, Italy; Dipartimento di Medicina e Riabilitazione Cardio-Respiratoria, Istituti Clinici Scientici Maugeri, IRCCS Tradate, Varese, Italy., de Llano LP; Pneumology Service, Hospital Universitario Lucus Augusti, EOXI Lugo, Cervo e Monforte, Spain Grupo BIOCHUS, Instituto de Investigación Sanitaria Santiago de Compostela (IDIS), Spain., Domingo Ribas C; Pulmonary Service, Corporació Sanitària Parc Taulí, Universitat Autònoma de Barcelona (UAB), Sabadell, Spain., Blakey JD; Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; Medical School, Curtin University, Perth, Australia., Garcia G; Pneumology, Pulmonary Service, Hospital R Rossi, La Plata, Argentina., Inoue H; Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan., Dalcolmo M; Reference Center Hélio Fraga, Fundação Oswaldo Cruz (Fiocruz)/Ministry of Health, Rio de Janeiro, Brazil., Yang D; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Mokashi S; GSK Brentford, Middlesex, UK., Kurne A; Global Medical Affairs, GSK, Asia House, Singapore., Butta AK; GSK, Asia House, Singapore.
Jazyk: angličtina
Zdroj: Respiratory medicine [Respir Med] 2022 Oct; Vol. 202, pp. 106942. Date of Electronic Publication: 2022 Aug 04.
DOI: 10.1016/j.rmed.2022.106942
Abstrakt: Purpose: Definitions and measures of asthma control used in clinical trials and in clinical practice vary considerably. There is also misalignment between patients and healthcare professionals (HCPs) in terms of understanding and managing asthma control. This study aimed to progress towards a consensus definition of asthma control, and evaluate disparities between HCP and patient perspectives.
Basic Procedures: A two-stage Delphi questionnaire involving asthma specialists sought to identify areas of consensus on aspects of asthma control in clinical practice. Results were compared with those of a structured literature review to assess if existing guidance and measures of asthma control used in studies correlated with practice. Eighty-two panelists took part in the Delphi questionnaire. The structured literature review included 185 manuscripts and 31 abstracts.
Main Findings: Panelists agreed that there was no standard definition of asthma control, confirmed by a total of 19 different composite consensus/guideline definitions and/or validated measures of control being identified across the Delphi study and literature review. Panelists agreed on the positive associations of well-controlled asthma with patient outcomes, but not on the components or thresholds of a working definition of control.
Principal Conclusions: A universally accepted definition and measure of asthma control that is utilized and understood by patients, HCPs, and researchers is required.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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