Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort study.

Autor: Garcia-Knight M; Department of Microbiology and Immunology, UCSF, California, United States of America., Anglin K; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Tassetto M; Department of Microbiology and Immunology, UCSF, California, United States of America., Lu S; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Zhang A; Department of Microbiology and Immunology, UCSF, California, United States of America., Goldberg SA; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Catching A; Department of Microbiology and Immunology, UCSF, California, United States of America., Davidson MC; School of Medicine, University of California, San Francisco, California, United States of America., Shak JR; School of Medicine, University of California, San Francisco, California, United States of America.; San Francisco VA Medical Center, San Francisco, California, United States of America., Romero M; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Pineda-Ramirez J; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Diaz-Sanchez R; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Rugart P; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Donohue K; School of Medicine, University of California, San Francisco, California, United States of America., Massachi J; School of Medicine, University of California, San Francisco, California, United States of America., Sans HM; School of Medicine, University of California, San Francisco, California, United States of America., Djomaleu M; School of Medicine, University of California, San Francisco, California, United States of America., Mathur S; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Servellita V; Division of Infectious Diseases, UCSF, California, United States of America., McIlwain D; Department of Microbiology and Immunology, Stanford, California, United States of America., Gaudiliere B; Department of Microbiology and Immunology, Stanford, California, United States of America., Chen J; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Martinez EO; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Tavs JM; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Bronstone G; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Weiss J; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Watson JT; Respiratory Viruses Branch, Division of Viral Diseases, CDC, Atlanta, Georgia, United States of America., Briggs-Hagen M; Respiratory Viruses Branch, Division of Viral Diseases, CDC, Atlanta, Georgia, United States of America., Abedi GR; Respiratory Viruses Branch, Division of Viral Diseases, CDC, Atlanta, Georgia, United States of America., Rutherford GW; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America., Deeks SG; Division of HIV, Infectious Disease, and Global Medicine, UCSF, California, United States of America., Chiu C; Division of Infectious Diseases, UCSF, California, United States of America., Saydah S; Respiratory Viruses Branch, Division of Viral Diseases, CDC, Atlanta, Georgia, United States of America., Peluso MJ; Division of HIV, Infectious Disease, and Global Medicine, UCSF, California, United States of America., Midgley CM; Respiratory Viruses Branch, Division of Viral Diseases, CDC, Atlanta, Georgia, United States of America., Martin JN; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America., Andino R; Department of Microbiology and Immunology, UCSF, California, United States of America., Kelly JD; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Institute for Global Health Sciences, University of California, San Francisco, California, United States of America.; San Francisco VA Medical Center, San Francisco, California, United States of America.; F.I. Proctor Foundation, University of California, San Francisco, California, United States of America.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2022 Sep 12; Vol. 18 (9), pp. e1010802. Date of Electronic Publication: 2022 Sep 12 (Print Publication: 2022).
DOI: 10.1371/journal.ppat.1010802
Abstrakt: The impact of vaccination on SARS-CoV-2 infectiousness is not well understood. We compared longitudinal viral shedding dynamics in unvaccinated and fully vaccinated adults. SARS-CoV-2-infected adults were enrolled within 5 days of symptom onset and nasal specimens were self-collected daily for two weeks and intermittently for an additional two weeks. SARS-CoV-2 RNA load and infectious virus were analyzed relative to symptom onset stratified by vaccination status. We tested 1080 nasal specimens from 52 unvaccinated adults enrolled in the pre-Delta period and 32 fully vaccinated adults with predominantly Delta infections. While we observed no differences by vaccination status in maximum RNA levels, maximum infectious titers and the median duration of viral RNA shedding, the rate of decay from the maximum RNA load was faster among vaccinated; maximum infectious titers and maximum RNA levels were highly correlated. Furthermore, amongst participants with infectious virus, median duration of infectious virus detection was reduced from 7.5 days (IQR: 6.0-9.0) in unvaccinated participants to 6 days (IQR: 5.0-8.0) in those vaccinated (P = 0.02). Accordingly, the odds of shedding infectious virus from days 6 to 12 post-onset were lower among vaccinated participants than unvaccinated participants (OR 0.42 95% CI 0.19-0.89). These results indicate that vaccination had reduced the probability of shedding infectious virus after 5 days from symptom onset.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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