Differential Markers of Subpopulations of Epithelial Cells of the Larynx in Squamous Cell Carcinoma.

Autor: Arutyunyan IV; Peoples' Friendship University of Russia (RUDN University), Moscow, Russia. labrosta@yandex.ru.; V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. labrosta@yandex.ru., Soboleva AG; A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia., Gordon KB; Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.; A. F. Tsyb Medical Radiological Research Center - Affiliated Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Kudashkina DS; P. A. Hertsen Moscow Oncology Research Institute - Affiliated Branch of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia., Miroshnichenko DA; P. A. Hertsen Moscow Oncology Research Institute - Affiliated Branch of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia., Polyakov AP; P. A. Hertsen Moscow Oncology Research Institute - Affiliated Branch of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia., Rebrikova IV; P. A. Hertsen Moscow Oncology Research Institute - Affiliated Branch of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia., Makarov AV; Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.; A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia., Lokhonina AV; Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.; A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia., Fatkhudinov TK; Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.; A. P. Avtsyn Research Institute of Human Morphology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Aug; Vol. 173 (4), pp. 553-559. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1007/s10517-022-05588-y
Abstrakt: In squamous cell carcinoma of the larynx, the population of epithelial cells in the tumor tissue is initially heterogeneous and, in addition to tumor cells invading the organ mucosa, includes normal epithelial cells of protein-mucous glands and cells of the stratified epithelium covering the mucous membrane. A search for differential markers to separate these subpopulations was carried out. The surface marker CD44 and cytokeratins 5 and 17 that are often used to verify carcinoma cells, are common markers for all epithelial cells of the larynx. In highly differentiated carcinoma, subpopulations of normal and tumor epithelial cells can be separated by the level of expression of cytokeratins 10 and 18 and nuclear markers Ki-67 and p63. However, in moderately differentiated carcinoma, tumor cells and normal cells of the basal layer of the stratified epithelium covering the mucous membrane of the larynx have similar phenotypes, which should be taken into account when conducting experimental studies.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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