Differential Adaptation of Biventricular Myocardial Kinetic Energy in Patients With Repaired Tetralogy of Fallot Assessed by MR Tissue Phase Mapping.

Autor: Ke SY; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan., Weng KP; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Chang MC; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan., Wu MT; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Li YH; Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Chien KJ; Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Lin CC; Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Hsieh KS; Department of Pediatrics, China Medical University Children's Hospital, Taichung, Taiwan., Chang MH; Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Pan JY; Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; Department of Cardiovascular Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Peng HH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2023 May; Vol. 57 (5), pp. 1492-1504. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1002/jmri.28420
Abstrakt: Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients.
Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM).
Study Type: Prospective.
Population: A total of 49 rTOF patients (23 ± 5 years old; male = 32), 47 normal controls (22 ± 1 year old; male = 29).
Field Strength/sequence: 3-T/2D dark-blood three-directional velocity-encoded gradient-echo sequence.
Assessment: Left and right ventricle (LV, RV) myocardial KE in radial (KE r ), circumferential (KE ø ), longitudinal (KE z ) directions. The proportions of KE in each direction to the sum of all KE (KE røz ): %KE r , %KE ø , %KE z . PR fraction.
Statistical Test: Student's t test, multivariable regression. Statistical significance: P < 0.05.
Results: In rTOF group, LV KE z remained normal in systole (P = 0.565) and diastole (P = 0.210), whereas diastolic LV %KE z (62% ± 14% vs. 72% ± 7%) and systolic LV %KE ø (9% ± 6% vs. 20% ± 7%) were significantly decreased. The KE r and %KE r of both ventricles significantly increased in the rTOF group (RV in diastole: 6 ± 3 vs. 3 ± 1 μJ and 54% ± 13% vs. 27% ± 7%). The rTOF group exhibited significantly higher RV/LV ratios of %KE r (systole: 1.3 ± 0.3 vs. 1.0 ± 0.3) and %KE ø (systole: 1.6 ± 0.8 vs. 1.0 ± 0.3) and significantly lower ratios of %KE z in systole (0.7 ± 0.2 vs. 1.0 ± 0.1) and diastole (0.5 ± 0.2 vs. 0.9 ± 0.1). In multivariable regression analysis, the RV peak systolic KE røz , RV systolic KE z , and LV diastolic %KE ø were independently associated with PR fraction in the rTOF group (adjusted R 2  = 0.479).
Data Conclusion: In rTOF patients, the adaptation of the KE proportion occurred earlier than that of the KE amplitude, and the biventricular balance of %KE was disrupted. PR may cause differential KE adaptation in RV and LV. TPM-derived KE may be useful in investigation of myocardial adaptation in rTOF patients.
Evidence Level: 2 TECHNICAL EFFICACY: Stage 3.
(© 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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